关键词: 联合切除术, 巨大肝癌, 局部脏器

Abstract: 【Abstract】 Objective〓To evaluate the safety and feasibility of hepatectomy combined with adjacent invaded organ(s) resection for the patients with large primary hepatic carcinoma (PHC). Methods〓A total of 571 patients, with large PHC (≥10 cm in diameter) received hepatectomy, were studied retrospectively at Tongji Hospital, Huazhong University of Science and Technology. Of these patients,38 cases underwent hepatectomy in combination with adjacent organ(s) resection because tumor invasion was suspected during operation (combined resection group). Subsequent histological examination of the resected specimens provided evidence showing that 17 cases of these patients with adjacent organ(s) resection were tumor invasion (invasion group), and the other 21 cases were non-tumor invasion (non-invasion group)..100 patients were selected as controls from 533 patients with large PHC without extrahepatic invasion randomly..Results...The operative mortality rate of combined resection group, invasion group and non-invasion group was 5.9%,.4.8% and 3.0%,.respectively..The incidence of complications of these three groups after operation was 64.7%,.66.7% and 45.0%,.respectively..The 1-,.2-,.3- and 5-year survival rates of these three groups were 64.7%,.41.2%,.29.4%,.5.9%; 57.1%, 38.1%, 28.6%, 9.5% and 65.0%, 44.0%, 34.0%, 13.0%, respectively. There were no significant differences between patients with and without extrahepatic PLC invasion on operative mortality, incidence of complication and overall survival rate. Conclusion〓Hepatectomy combined with adjacent invaded organ(s) resection is safe and feasible, and similar effect between patients with and without adjacent invaded organ(s) was obtained.

Key words: Adjacent invaded organ(s), Huge primary hepatic carcinoma, Hepatectomy