关键词: 血清骨代谢, 氧化应激指标, 血小板, 青少年骨折, 临床意义

Abstract: 【Abstract】 Objective To investigate the bone metabolism, platelet activation and oxidative stress responses of young patients with bone fracture, and to study its clinical significance. Methods From August 2012 to October 2014, 78 cases of young patients with fracture in our hospital were recorded as the observation group. And then 78 young people for health examination at the same period were recruited as the control group. Serum bone metabolism, platelets activity,oxidative stress, blood lipids of patients were observed in two groups and compared between two groups. Results Serum levels of bone metabolism (OPG, HCT, IGF- II and ALP), Platelet activity (PAC-1, GMP-140, CD61 and CD63) of the observation group at 7 days showed an upward trend, and the overall level was higher than that of the control group. And platelet activating levels returned to normal levels at the 14th days, but the level of bone metabolism continued to rise. In addition, the levels of oxidative stress index (SOD, TAC, CAT and MDA), blood lipid (TC, TG, and HDL-C) of the observation group at 7 days showed a decreasing trend, and the levels were lower than those of the control group. And all returned to normal level at the 14th days. Conclusion〓Fractures in the young patients result in substantial changes in serum levels of bone metabolism, platelet activities and oxidative stress index, which is helpful for deeper study for traumatic fractures.

Key words: Adolescent fracture, Platelet, Oxidative stress index, Serum bone metabolism, Clinical significance