关键词: 依达拉奉, 炎症相关因子, 老年患者, 术后早期认知功能障碍

Abstract: 【Abstract】〓Objective〓To evaluate the effect of edaravone on inflammatory cytokines and early stage postoperative cognitive dysfunction in elderly patients undergoing orthopedic surgery. Methods Sixty patients (ASA I-Ⅲ) aged 65 and over, undergoing hip joint surgery under general anesthesia, were assigned to groups (n=30, each group), control group (group C) and edaravone group (group E). Group E was treated with 30 mg of edaravone plus 100 ml saline for administration of intravenous drip. Group C was use 100 ml normal saline alone. The venous blood samples were drawn after induction of anesthesia (T1), at the end of surgery (T2), 24 hours after surgery (T3). The levels of IL-6, IL-10, TNF-α and S100-β were measured. The cognitive function in all patients at 1 day before surgery and 1 day,7 days after surgery was assessed by using Mini- Mental State(MMSE) test. POCD was defined as the difference between preoperative and postoperative mean MMSE score decline ≥2 points. Results〓Compared with T1, the levels of IL-6, IL-10, TNF-α and S100-β at T2 and T3 were significantly increased (all P values <0.05). The levels of IL-6, TNF-α at T3 in group C, were significantly increased than that in group E (all P values <0.05). Compared with group C, The levels of S100-β in group E at T2 and T3 were significantly decreased (P<0.05, vs group C). Compared with 1 day before surgery, the MMSE score were significantly declined at 1 day after surgery (P<0.05). Compared with group C, the MMSE score were significantly increased in group E at 1 day after surgery (P<0.05). The occurrence rate of POCD in group E were lower than that of group C at 1 day after surgery (P<0.05). Conclusion〓To a certain extent, edaravone could impair inflammatory reaction and reduce the incidence of POCD in elderly patients undergoing orthopedic surgery.

Key words: Edaravone, Inflammatory cytokines, Postoperative cognitive dysfunction, Elderly patients