关键词: 继发性损伤, 酮体, 神经保护, 颅脑创伤

Abstract: 【Abstract】〓Traumatic brain injury could resulted in hypoxia-ischemia of brain tissue. It would lead to a series of pathophysiological changes,.including secondary inflammation,.cephalophyma, encephaledema, increased intracranial pressure..Secondary brain injury is the primary cause of deterioration of diseases and death or disability of patients..The post traumatic glucose metabolic disturbance can worsen the metabolic condition of neuron. Ketone diet is a diet therapy with high fat, low carbohydrates and protein. The energy source of body comes from lipometabolism instead of carbohydrates. The ketogenic diet had been applied in clinical antiepileptic therapy. The late research demonstrates that ketogenic diet post-traumatically could affect the neuron apoptosis. It could also alleviate the brain edema to protect the neuron. In this paper, we would review the neuroprotective effect of ketone metabolism on brain post traumatic brain injury.

Key words: Ketone body, Secondary injury, Neuroprotection, Traumatic brain injury