关键词: 腹腔灌注, 生存率, 进展期结直肠癌, 温热低渗液化疗

Abstract: 【Abstract】 Objective To evaluate the clinic effects of hyperthermic intraperitoneal perfusion chemotherapy (HIPEC) combined with venous chemotherapy for the treatment of advanced colorectal cancer. Methods〓Sixty-five cases of advanced colorectal cancer were divided into HIPEC group (n=30)and control group(n=35)..After radical resection,HIPEC were combined the FOLFOX6 chemotherapy plan in experiment group. Whereas the control group were received FOLFOX6 chemotherapy plan only. The clinical effect and prognosis were compared. Results〓The KPS scale increasing rate were 53.33% in HIPEC group and 40.00% in control group respectively..The variation between the two groups achieved statistical significance(P<0.05)..Two adverse reactions are reversible,.and became better after discontinuation..The incidence rate of hypoproteinemia were 20.0% at the third day after operation..There were no severe complications occurred in two groups..And there were no significant increase about the incidence rate of overall postoperative complications..The local recurrence and liver metastasis rate of HIPEC group were significantly lower than the control group,the difference was statistically significant (χ2=18.056, χ2=10.187, all P values were less than 0.05). The 1-, 3-, and 5-year survival rates in treatment group were 97.3%, 71.8%, 50.9% and 96.7%, 60.3%, 39.2% in control group respectively. The 1-year survival rate achieved no statistical significance (P>0.05), but the 3- and 5-year survival rates achieved statistical significance between the two groups(all P values were less than 0.05). Conclusion〓When combined with venous chemotherapy, (HIPEC was safe, reliable.It can improve the quality of life and raise the 3- and 5-year survival rate of the advanced colorectal cancer patients significantly. It was effective adjuvant treatment to colorectal cancer.

Key words: Hyperthermic hypotonic chemotherapy, Survival rate, Advanced colorectal cancer, Intraperitoneal perfusion