关键词: 乳腺癌, AKIP1, P65, 肿瘤分化, 免疫组织化学

Abstract: 【Abstract】 Objective To investigate the expression and cinical significance of AKIP1 and P65 in breast carcinoma. Methods〓Eighty-nine tissue specimens of breast carcinoma and 30 tissue specimen of paraneoplastic mammary gland were selected and stained with immunohistochemistry with SP ways. The express disparity of AKIP1 and P65 were contrasted between breast carcinoma and paraneoplastic mammary gland. The correlation of AKIP1 expression and P65 expression with biological behavior of breast carcinoma and correlation of AKIP1 expression with P65 expression in breast carcinoma were analyzed. Results〓The expression of AKIP1(56.2%) was lower in breast carcinoma than in paraneoplastic mammary gland(93.3%,P<0.01). The expression of P65 (85.4%) was higher in breast carcinoma than in paraneoplastic mammary gland(55.0%,P<0.01). The expression of AKIP1 and P65 was negative correlation in breast carcinoma(r=-0.704, P<0.01). The expression of AKIP1 and P65 were discrepant in breast carcinoma with different differentiation and lymph node metastasis(P<0.01). Conclusion〓The expression of AKIP1 and over-expression of P65 in breast carcinoma tissue may be early and high malignant in breast carcinoma.

Key words: Breast carcinoma, AKIP1, P65, Immunohistochemistry