关键词: 丙泊酚, 躁动, 血流动力学, 咪达唑仑, 老龄

Abstract: 【Abstract】〓Objective〓To investigate the effect of midazolam combined with propofol on controlling emergence agitation and influencing hemodynamic changes in the awaking stage of general anesthesia. Methods〓From January 2014 to February 2015, 80 patients (more than 65 years old) undergoing abdominal and orthopaedic surgery were included in the study, and were assigned observation groups (n=40) and control group (n=40). The patients of control group were treated midazolam combined fentanyl to induce and maintain general anesthesia, and those of observation group received midazolam in combination with propofol. The emergence agitation and hemodynamics in general anesthesia patients were observed and compared in two groups, including before anesthesia induction (T0), 1 min after induction (T1), (T2) before the endotracheal intubation, endotracheal intubation (T2) immediately 1 min (T3), endotracheal intubation, endotracheal intubation, 5 min (T4), endotracheal intubation, 10 min (T5), endotracheal intubation, 20 min (T6). Results〓The levels of MAP and HR in T1, T2, T3, T4, T5, T6 in observation group were lower than that in control group (P<0.05). Case number of stir class I and stir class Ⅲ during the awakening period in observation group was less than that in control group (5.0% vs 22.5%, 2.5% vs 17.5%, respectively, P<0.05). Conclusion The present study showed that midazolam in combination with propofol was more advantageous to maintain hemodynamic stability of the aged patients with general anesthesia, reduce the incidence of general awakening period agitation.

Key words: Propofol, Hemodynamic, Midazolam, Aging, Restlessness