关键词: 前列腺癌, 无生化复发生存, 组织芯片, TRIB1, Gleason评分

Abstract: 【Abstract】〓Objective〓To study the expression and significances of TRIB1 in benign prostate hyperplasia(BPH) tissues and prostate cancer tissues, and to illustrate the correlation with clinical significance and outcomes. Methods〓The dataset of whole genomic expression profiles got from the prostate tissues were obtained from gene expression omnibus (GEO) database. The samples were derived from benign prostatic tissues and prostatic carcinoma tissues of the patients with BPH or prostatic cancer..Immunohistochemistry analyses were conducted to detect the expression of TRIB1 protein in both prostate cancer and BPH tissues,.and further statistically analyzed the correlations with clinic pathological characteristics and outcomes of the patients with prostate cancer. Results〓The expression of TRIB1 protein was significantly increased in prostate cancer tissues compared with BPH tissues (P<0.01)..The expression rate of TRIB1 protein was in relation with Gleason score (P<0.01) and clinical stage (P=0.02). The upregulation of CENPF mRNA expression in the PCa tissues significantly correlated with a higher Gleason score.(P=0.02),.an advanced pathological stage.(P=0.01).and poor biochemical recurrence.(BCR)-free survival.(P=0.047). Conclusion〓Our study showed the increased expression of both TRIB1 protein and mRNA levels plays an important role in the progression of PCa. More importantly, the increased expression of TRIB1 may efficiently predict poor BCR-free survival in patients with PCa.

Key words: Prostate cancer, Tissue microarray, TRIB1, Gleason score, Biochemical recurrence-free survival