关键词: 隐性胰胆逆流, 胆囊癌, 淀粉酶

Abstract: 【Abstract】〓Objective〓To study the value of occult pancreaticobiliary reflux in the early diagnosis of patients with gallbladder cancer. Methods〓The date of 86 patients of normal pancreaticobiliary junction evidenced by operative cholangiography with gallbladder cancer in our hospital from June 2007 to April 2011 were retrospectively analyzed. The information of imageology and the bile amylase level of cystic was detected,and were compared with the intraoperative exploration findings and postoperative pathological diagnosis. The bile amylase levels of 56 consecutive patients with cholecystolithiasis and 22 hilus holangiocarcinoma were detected. Results〓The mean (SD) biliary amylase level of 86 patients of gallbladder cancer was 752.6 (341.8) U/L, and cholecystolithiasis was 76.7(68.3) U/L. 61(70.1%) of gallbladder cancer the biliary amylase level above that of normal serum. Conclusion〓The incidence of occult pancreatobiliary reflux were higher with gallbladder carcinoma,and pancreaticobiliary reflux that might play an important role in the pathogenesis of gallbladder cancer.

Key words: Gallbladder cancer, Occult pancreaticobiliary reflux, Early diagnosis