坏死性凋亡在恶性肿瘤中的研究进展

doi:10.3969/j.issn.1009-976X.2016.01.029

岭南现代临床外科 ›› 2016, Vol. 16 ›› Issue (01): 111-114.DOI: 10.3969/j.issn.1009-976X.2016.01.029

坏死性凋亡在恶性肿瘤中的研究进展

余永晟李金黄海赖义明陈贤举郭正辉

中山大学孙逸仙纪念医院泌尿外科

通讯作者: 郭正辉

Development of necroptosis in malignant tumor

YU Yongsheng, LI Jin, HUANG Hai, LAI Yiming, CHEN Xianju, GUO Zhenghui

Received:2016-03-14 Online:2016-02-20 Published:2016-02-20

摘要/Abstract

摘要：

【摘要】〓经典理论认为,细胞死亡一般有凋亡和坏死两种途径。近年来大量研究发现坏死性凋亡在肿瘤疾病发生、进展与耐药过程中发挥重要作用。坏死性凋亡是一种可调控性的非依赖Caspase的程序性坏死。本文综述了近年来关于坏死性凋亡的机制探索,及其在恶性肿瘤的发生进展与抗肿瘤药物中的研究,从而进一步认识坏死性凋亡于恶性肿瘤的研究价值。

关键词: RIP1, 恶性肿瘤, RIP3, 治疗靶点, 坏死性凋亡

Abstract:

【Abstract】 According to traditional theory, cell death is clarified into apoptosis and necrosis. However, a range of researches reveal that necroptosis contribute to a plenty of human disease, especially tumorigenesis, progression and chemoresistance. Necroptosis is the programed necrosis which is independent of caspase activation. This review summarizes the research progress on mechanism of necroptosis, the role of necroptosis in cancer and and its value in drug targets, in order to achieve an improvement of necroptosis in cancer research.

Key words: Necroptosis, Malignant tumor, RIP3, RIP1, Therapeutic target

中图分类号:

R730.2

余永晟李金黄海赖义明陈贤举郭正辉. 坏死性凋亡在恶性肿瘤中的研究进展[J]. 岭南现代临床外科, 2016, 16(01): 111-114.

YU Yongsheng, LI Jin, HUANG Hai, LAI Yiming, CHEN Xianju, GUO Zhenghui. Development of necroptosis in malignant tumor[J]. Lingnan Modern Clinics in Surgery, 2016, 16(01): 111-114.

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坏死性凋亡在恶性肿瘤中的研究进展

Development of necroptosis in malignant tumor

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