关键词: Ki67, PR, P53, 乳腺癌, Luminal A, Luminal B, 无病生存

Abstract: 【Abstract】 Objective〓The objective of this study were to determine the DFS(disease free survival) prognostic significance of subgrouping Luminal breast tumors into low- and high-risk luminal categories by using Ki67, PR, or P53 status and analyze whether the various methods can identify the same patients as being in the poor prognostic group. Methods〓Patients with early invasive breast cancer who were treated between March 2006 and December 2013,.were selected by searching breast tumor registries at Sun Yat-sen Memorial Hospital. Patient characteristics were collected. The primary outcome measured was DFS which was estimated using Kaplan-Meier test and a log-rank test was used to compare survival curves. Cox regression analysis was used to balance the risk factors for prognosis between groups. Kappa statistics were calculated among the three biomarkers. Results〓A total of 1107 patients with invasive breast cancer were eligible for inclusion in the study. Ki67, PR and P53 in the subclassification of Luminal tumors was all found to be of prognostic significance or independent prognostic significance on univariate analysis and multivariate analysis. They identified the different patients as being in the poor prognostic group. Conclusion〓In order to optimize patient management, better combination of these biomarkers need further explored.

Key words: Ki67, PR, P53, Breast cancer, Luminal A, Luminal B, Recurrence freesurvival