关键词: 131I, 甲状腺癌, 唾液腺功能, 甲状腺球蛋白抗体

Abstract: 【Abstract】〓Objective〓To investigate the effect of the postoperative 131I treatment on salivary gland function and Thyroglobulin antibody (TgAb) for thyroid carcinoma. Methods〓Seventy-nine cases of thyroid carcinoma surgery patients in our hospital were included. Forty patients were treated with 150 mCi 131I (150 mCi group) and thirty-nine patients with 80 mCi 131I (80 mCi group). Salivary gland function and TgAb levels of patients were compared between the two groups. Results〓Effective rate of 150 mCi group was slightly higher than of 80 mCi group, but it had not statistically significant difference between the two groups. Saliva pH value and salivary buffer pH value of 150 mCi group were significantly higher than 80 mCi group. Salivary flow rate was significantly lower than 80 mCi group(P<0.05),and 3,6 months after 131I therapy, the average TgAb of 150 mCi group were significantly lower than 80 mCi group (P<0.05). Conclusion〓In our study, the effect of 131I therapy was remarkable for treatment of thyroid carcinoma, and it had less adverse reaction in low dose 131I therapy, but the TgAb more dropping degree in high dose 131I therapy.

Key words: 131I, Thyroid carcinoma, Salivary gland function, Thyroid globulin antibody