关键词: 肝细胞癌, ICG, 肝储备功能, 肝功能不全

Abstract: 【Abstract】 Objective〓To evaluate the effect of indocyanine green clearance test at 15 min (ICGR15) on assessing preoperative liver reserve function in patients with hepatocellular carcinoma(HCC). Methods〓Sixty-three diagnosed HCC patients who had undergone hepatectomy from June 2012 to July 2013 were enrolled in this study. According to the quantity of ICGR15, the patients were divide into different groups, and the recovery of postoperative liver function were compared during different groups. The clinic data were analyzed by logistic regression analyze. Results〓The incidence rate of liver dysfunction in the ICGR15≥10% group was significantly increased than that in the ICGR15<10% group(68.2% vs 19.5%, P<0.05). The quantity of ICGR15 in Child-pugh B group were significantly increased than that in Child-pugh A group(19.01%±11.14% vs 7.57%±8.34%, P<0.05), and ICGR15 was correlated with Child-pugh score (P<0.05, r=0.313). The specificity of ICGR15 to predict recovery of postoperative liver function was 82.5%,which increased significantly than that of OGTT(P<0.05), and 65.2% with sensibility, 68.2% with positive predictive value, 80.5% with negative predictive value of ICGR15, which were all no statistical significance when comparing with OGTT (P>0.05). ICGR15 was associated with postoperative liver function (P<0.05, r=0.434), while OGTT negatively correlated with postoperative liver function (P>0.05). Logistic regression analyze revealed that ICGR15, vessel cancer embolus, blood loss and other operative complication were independent risk factors for postoperative liver dysfunction. Conclusion〓In the present study, ICGR15 showed a high sensitivity and specificity in assessing preoperative liver reserve function in patients with hepatocellular carcinoma, and was exact to predict recovery of postoperative liver function.

Key words: HCC, Indocyanine green clearance, Liver reserve function, Liver dysfunction