岭南现代临床外科 ›› 2015, Vol. 15 ›› Issue (03): 235-242.DOI: 10.3969/j.issn.1009-976X.2015.03.001
• 专家述评 • 下一篇
黄静文,梁碧玲
通讯作者:
梁碧玲
Received:
2015-05-20
Revised:
2015-06-06
Online:
2015-06-20
Published:
2015-06-20
摘要:
自20世纪90年代以来,不断有新的肝细胞特异性对比剂研发和应用于肝脏的磁共振检查。这些对比剂通过不同的途径经正常肝细胞摄取、分泌进入胆道系统,可用于诊断肝细胞来源和非肝细胞来源的肝内结节性病变,还可用于胆道疾病的诊断。肝细胞特异性对比剂的临床应用为肝脏疾病的诊断提供了重要帮助,本文将对肝细胞特异性对比剂的特性、临床应用及研究进展做系统的综述。
中图分类号:
黄静文 梁碧玲. 磁共振肝细胞特异性对比剂的临床应用[J]. 岭南现代临床外科, 2015, 15(03): 235-242.
[1]李连第,张思维,鲁凤珠.中国恶性肿瘤死亡谱及分类构成特征研究[J].中华肿瘤杂志, 1997, 第19卷(第5期):323-328 [2]Stark D D, Wittenberg J, Butch R J, et al.Hepatic metastases: randomized,controlled comparison of detection with MR imaging and CT[J].Radiology, 1987, 165(2):399-406 [3]Rummeny E J, Wernecke K, Saini S, et al.Comparison between high-field-strength MR imaging and CT for screening of hepatic metastases: a receiver operating characteristic analysis[J].Radiology, 1992, 182(3):879-886 [4]Semelka R C, Shoenut J P, Kroeker M A, et al.Focal liver disease: comparison of dynamic contrast-enhanced CT and T2-weighted fat-suppressed,FLASH,and dynamic gadolinium-enhanced MR imaging at 15 T[J].Radiology, 1992, 184(3):687-694 [5]Palma L D.Diagnostic imaging and interventional therapy of hepatocellular carcinoma[J].Br J Radiol, 1998, 71(848):808-818 [6]Mahfouz A E, Hamm B, Taupitz M, et al.Hypervascular liver lesions: differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging[J].Radiology, 1993, 186(1):133-138 [7]Frazer C.Imaging of hepatocellular carcinoma[J].J Gastroenterol Hepatol, 1999, 14(8):750-756 [8]Coffin C M, Diche T, Mahfouz A, et al.Benign and malignant hepatocellular tumors: evaluation of tumoral enhancement after mangafodipir trisodium injection on MR imaging[J].Eur Radiol, 1999, 9(3):444-449 [9]Burke C, Alexander Grant L, Goh V, et al.The Role of Hepatocyte-Specific Contrast Agents in Hepatobiliary Magnetic Resonance Imaging[J].Seminars in Ultrasound, CT and MRI, 2013, 34(1):44-53 [10]Schuhmann-Giampieri G.Liver contrast media for magnetic resonance imagingInterrelations between pharmacokinetics and imaging[J].Invest Radiol, 1993, 28(8):753-761 [11]Kirchin M A, Pirovano G P, Spinazzi A.Gadobenate dimeglumine (Gd-BOPTA)An overview[J].Invest Radiol, 1998, 33(11):798-809 [12]Schuhmann-Giampieri G, Schmitt-Willich H, Press W R, et al.Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system[J].Radiology, 1992, 183(1):59-64 [13] Dahlstr?m N.Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI[J]. 2010:20-23. [14]Van Beers B E, Pastor C M, Hussain H K.Primovist,Eovist: what to expect?[J].J Hepatol, 2012, 57(2):421-429 [15]Kitao A, Matsui O, Yoneda N, et al.The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging[J].European Radiology, 2011, 21(10):2056-2066 [16]Bellin M.MR contrast agents,the old and the new[J].European Journal of Radiology, 2006, 60(3):314-323 [17]Hamm B, Staks T, Hler A M, et al.Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety,pharmacokinetics,and MR imaging[J].Radiology, 1995, 195(3):785-792 [18]Vogl T J, Kummel S, Hammerstingl R, et al.Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA[J].Radiology, 1996, 200(1):59-67 [19]Hamed M M, Hamm B, Ibrahim M E, et al.Dynamic MR imaging of the abdomen with gadopentetate dimeglumine: normal enhancement patterns of the liver,spleen,stomach,and pancreas[J].AJR. American journal of roentgenology, 1992, 158(2):303-307 [20]Kim H J, Kim B S, Kim M J, et al.Enhancement of the liver and pancreas in the hepatic arterial dominant phase: Comparison of hepatocyte-specific MRI contrast agents,gadoxetic acid and gadobenate dimeglumine,on 3 and 15 tesla MRI in the same patient[J].Journal of Magnetic Resonance Imaging, 2013, 37(4):903-908 [21]Kirchin M A, Pirovano G, Venetianer C, et al.Safety assessment of gadobenate dimeglumine (MultiHance): extended clinical experience from phase I studies to post-marketing surveillance[J].J Magn Reson Imaging, 2001, 14(3):281-294 [22]Reimer P, Schneider G N, Schima W.Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties,clinical development and applications[J].European Radiology, 2004, 14(4):559-578 [23]Reimer P, Rummeny E J, Shamsi K, et al.Phase II clinical evaluation of Gd-EOB-DTPA: dose,safety aspects,and pulse sequence[J].Radiology, 1996, 199(1):177-183 [24].[J]., 2004, 14(4):559-578 [25]Dahlstrom N, Persson A, Albiin N, et al.Contrast-enhanced magnetic resonance cholangiography with Gd-BOPTA and Gd-EOB-DTPA in healthy subjects[J].Acta Radiol, 2007, 48(4):362-368 [26]Smith A D, Veniero J C.Gd-EOB-DTPA as a functional MR cholangiography contrast agent: imaging gallbladder filling in patients with and without hepatobiliary dysfunction[J].J Comput Assist Tomogr, 2011, 35(4):439-445 [27]Tschirch F T C, Struwe A, Petrowsky H, et al.Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma[J].European Radiology, 2008, 18(8):1577-1586 [28]Lee N K, Kim S, Lee J W, et al.Biliary MR imaging with Gd-EOB-DTPA and its clinical applications[J].Radiographics, 2009, 29(6):1707-1724 [29]Bashir M R, Husarik D B, Ziemlewicz T J, et al.Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: Does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?[J].Journal of Magnetic Resonance Imaging, 2012, 35(3):611-616 [30]Kim T K, Lee K H, Jang H J, et al.Analysis of gadobenate dimeglumine-enhanced MR findings for characterizing small (1-2-cm) hepatic nodules in patients at high risk for hepatocellular carcinoma[J].Radiology, 2011, 259(3):730-738 [31]Tsuboyama T, Onishi H, Kim T, et al.Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation[J].Radiology, 2010, 255(3):824-833 [32]Choi S H, Lee J M, Yu N C, et al.Hepatocellular carcinoma in liver transplantation candidates: detection with gadobenate dimeglumine-enhanced MRI[J].AJR Am J Roentgenol, 2008, 191(2):529-536 [33]Hammerstingl R, Huppertz A, Breuer J, et al.Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions[J].Eur Radiol, 2008, 18(3):457-467 [34]Grazioli L, Morana G, Kirchin M A, et al.Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: prospective study[J].Radiology, 2005, 236(1):166-177 [35]Doi N, Tomiyama Y, Kawase T, et al.Focal Nodular Hyperplasia-Like Nodule with Reduced Expression of Organic Anion Transporter 1B3 in Alcoholic Liver Cirrhosis[J].Internal Medicine, 2011, 50(11):1193-1199 [36]Okada M, Ishii K, Numata K, et al.Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?[J].Hepatobiliary & Pancreatic Diseases International, 2012, 11(3):307-313 [37] 罗宴吉,蔡华崧,汤地,等.肝细胞特异性MR对比剂在肝脏功能评价中的初步研究[J][J].中华消化病与影像杂志(电子版), 2013, 3(05):242-246 [38]Motosugi U, Ichikawa T, Sou H, et al.Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: Which biological markers of the liver function affect the enhancement?[J].Journal of Magnetic Resonance Imaging, 2009, 30(5):1042-1046 [39]廖承德,梁碧玲,钟镜联,等.增强胆道造影在非重度胆道梗阻中的临床应用初探[J].实用放射学杂志, 2010, 26(6):843-846 [40]Gupta R T.Evaluation of the Biliary Tree and Gallbladder With Hepatocellular MR Contrast Agents[J].Current Problems in Diagnostic Radiology, 2013, 42(2):67-76 [41]Lim J S, Kim M J, Kim J H, et al.Preoperative MRI of potential living-donor-related liver transplantation using a single dose of gadobenate dimeglumine[J].AJR Am J Roentgenol, 2005, 185(2):424-431 [42]Krol R, Karkoszka H, Ziaja J, et al.Biliary complications after orthotopic liver transplantation: a 5-year experience[J].Transplant Proc, 2011, 43(8):3035-3038 [43]Masci E, Toti G, Mariani A, et al.Complications of diagnostic and therapeutic ERCP: a prospective multicenter study[J].Am J Gastroenterol, 2001, 96(2):417-423 [44]Fontarensky M, Montoriol P F, Buc E, et al.Advantages of gadobenate dimeglumine-enhanced MR cholangiography in the diagnosis of post-liver transplant bile leakage[J].Diagnostic and Interventional Imaging, 2013, 94(4):443-452 [45]Cieszanowski A, Stadnik A, Lezak A, et al.Detection of active bile leak with Gd-EOB-DTPA enhanced MR cholangiography: Comparison of 20–25min delayed and 60–180min delayed images[J].European Journal of Radiology, 2013, 82(12):2176-2182 [46]Choi I Y, Yeom S K, Cha S H, et al.Diagnosis of biliary stone disease: T1-weighted magnetic resonance cholangiography with Gd-EOB-DTPA versus T2-weighted magnetic resonance cholangiography[J].Clinical Imaging, 2014, 38(2):164-169 [47]宁浩勇,虞积耀.消化系统肿瘤组织学分类[J].诊断病理学杂志, 2011, 18(1):77-79 [48]Wan X.Intraductal papillary neoplasm of the bile duct[J].World Journal of Gastroenterology, 2013, 19(46):8595-8604 [49]Yeh T, Tseng J, Chiu C, et al.Cholangiographic Spectrum of Intraductal Papillary Mucinous Neoplasm of the Bile Ducts[J].Annals of Surgery, 2006, 244(2):248-253 [50] Ohtsuka M, Shimizu H, Kato A, et al.Intraductal Papillary Neoplasms of the Bile Duct[J][J]., 2014, 2014(2014):1-10 [51]Park M, Yu J, Lee D K, et al.Gadobenate dimeglumine–enhanced MRI of intraductal papillary mucinous tumor of the bile ducts[J].Journal of Magnetic Resonance Imaging, 2007, 25(3):625-627 [52]Ergen F B, Akata D, Sarikaya B, et al.Visualization of the biliary tract using gadobenate dimeglumine: preliminary findings[J].J Comput Assist Tomogr, 2008, 32(1):54-60 [53]Wu Z, Matsui O, Kitao A, et al.Usefulness of Gd-EOB-DTPA-enhanced MR imaging in the evaluation of simple steatosis and nonalcoholic steatohepatitis[J].Journal of Magnetic Resonance Imaging, 2013, 37(5):1137-1143 [54]Williams R.Global challenges in liver disease[J].Hepatology, 2006, 44(3):521-526 [55] 袁平戈.非酒精性脂肪性肝病的诊断和治疗探讨[J]., 2009(02):333-336.[J].西部医学, 2009, 2(21):333-336 [56]Tsuda N, Okada M, Murakami T.New proposal for the staging of nonalcoholic steatohepatitis: Evaluation of liver fibrosis on Gd-EOB-DTPA-enhanced MRI[J].European Journal of Radiology, 2010, 73(1):137-142 [57]Bastati N, Feier D, Wibmer A, et al.Noninvasive differentiation of simple steatosis and steatohepatitis by using gadoxetic acid-enhanced MR imaging in patients with nonalcoholic fatty liver disease: a proof-of-concept study[J].Radiology, 2014, 271(3):739-747 [58]Tsuda N, Okada M, Murakami T.Potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for differential diagnosis of nonalcoholic steatohepatitis and fatty liver in rats using magnetic resonance imaging[J].Invest Radiol, 2007, 42(4):242-247 |
[1] | 谭勇, 刘晖, 吴黎明, 刘文瑛, 欧阳再兴, 胡竻生, 宋灏, 黄从云, 吴青松. 乙型肝炎病毒DNA载量与肝癌切除术后肝功能变化关系的研究[J]. 岭南现代临床外科, 2024, 24(04): 209-214. |
[2] | 吴海丰, 黄亚珍, 李芬, 姚沛旭. 肝动脉解剖学变异在肝脏手术中的分布及意义[J]. 岭南现代临床外科, 2024, 24(04): 220-224. |
[3] | 郑彪, 陈旭, 钱均霖, 许宝石, 甄潮辉, 梁锐. RAD54B在肝细胞癌中的表达及对临床预后的影响[J]. 岭南现代临床外科, 2024, 24(04): 225-230. |
[4] | 熊峰, 樊丽敏, 张丹图, 纪任. 肝癌根治性切除术“教科书式结局”研究进展[J]. 岭南现代临床外科, 2023, 23(06): 520-封三. |
[5] | 罗旋, 龙吟, 黄子棋, 何晓东, 黄珏, 廖建国, 张磊. mFOLFOX系统性化疗联合靶向免疫方案治疗不可切除肝细胞癌的真实世界数据初步分析[J]. 岭南现代临床外科, 2023, 23(04): 294-301. |
[6] | 陈茜, 陈捷, 陈涛, 陈亚进. 2023年V1版NCCN肝细胞癌临床实践指南更新解读[J]. 岭南现代临床外科, 2023, 23(02): 95-99. |
[7] | 李天伟, 杨宗锐, 邰升. 肝脏局灶性结节性增生的诊治进展[J]. 岭南现代临床外科, 2022, 22(06): 595-599. |
[8] | 廖小慧, 杨长青, 魏子白. 肝硬化中的血小板变化机制及影响[J]. 岭南现代临床外科, 2022, 22(06): 600-605. |
[9] | 于飞, 李强, 王开宇, 张琪佳, 肖鸣, 王良, 雷建军, 崔贵医, 徐光勋, 项灿宏. 围肝门切除联合S2、3、4段切除治疗肝门部胆管癌[J]. 岭南现代临床外科, 2022, 22(05): 433-440. |
[10] | 罗发, 严庆, 陈焕伟. 腹腔镜肝切除治疗肝细胞癌的安全性和长期疗效观察[J]. 岭南现代临床外科, 2022, 22(05): 441-445. |
[11] | 陈秋凯, 戴维. 吲哚菁绿在肝胆腹腔镜手术领域中的应用现状[J]. 岭南现代临床外科, 2022, 22(05): 520-525. |
[12] | 叶少炜, 钱均霖, 胡泽民. 肝移植后代谢综合征及其防治的研究进展[J]. 岭南现代临床外科, 2022, 22(02): 199-204. |
[13] | 李硕, 林杰, 王卫东. 5例肝血管平滑肌脂肪瘤的诊断与治疗分析[J]. 岭南现代临床外科, 2022, 22(01): 56-60. |
[14] | 左超海, 覃芝蓉, 余杰雄, 潘德盛, 邝乃乐, 黄皓川. 标准化剩余肝体积与肝硬度比值预测肝脏切除术后肝功能不全的临床研究[J]. 岭南现代临床外科, 2022, 22(01): 61-65. |
[15] | 赵宁波, 黄秀玲, 张瑜, 周丹, 李一君, 邓芬, 黄佳, 冯程, 胡红星. 常规超声和超声造影在肝移植术后活动性出血的诊断价值对比[J]. 岭南现代临床外科, 2021, 21(06): 620-624. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||