关键词: 围手术期, 高血糖, 胰岛素强化治疗, 持续性皮下胰岛素输注

Abstract: 【Abstract】〓Objective〓To explore the effect of short-term intensive insulin therapy in patients with hyperglycemia on beta cell function in perioperative period. Methods〓From January 2011 to July 2013 in our hospital, forty-five patients in perioperative period with hyperglycemia were underwent short-term intensive therapy (continuous subcutaneous insulin infusion, CSII group, n=25; multiple subcutaneous insulin injection, MSII group, n=20). The data of FBG, 2hPG, blood glucose GSP, beta cell function and insulin sensitivity index and the changes of TNF-α, IL-1β, CRP and APN were compared between the two groups. Results〓After the treatment, the patients of CSII group and MSII group showed significantly decreased FBG, 2hPG and GSP levels (P<0.05). Both CSII group and MSII group showed significantly lower FCP and Homa-IR levels, and higher Homa-β after treatment (P<0.05). CSII group demonstrated more significantly improvement compared with MSII (P<0.05). And the same changes of TNF-α, IL-1β, CRP, and APN levels were observed after treatment in CSII group compared with MSII group. Conclusion〓The continuous subcutaneous insulin therapy can effectively control blood glucose and improve islet function and insulin sensitivity,which is involved by reducing inflammation.

Key words: Perioperative period, Hyperglycemia, Intensive insulin therapy, Continuous subcutaneous insulin therapy