关键词: 急性胰腺炎, 血液净化, 肠道去污

Abstract: 【Abstract】〓Objective〓To observe the therapeutic effect of early blood purification combined with early selective digestive tract decontamination (SDD) on treatment of severe acute pancreatitis. Methods〓A retrospective analysis was performed in the 39 SAP patients admitted to Dongguan People’s Hospital from March 2012 to March 2015. The patients were divided into intervention group (n=21) and control group (n=19). The patients of intervention group were treated with early blood purification combined with early SDD, and the controls received conventional treatment. Clinical outcomes of post-treatment were assessed, including the time of bladder pressure below 15 mmHg, the time of vasoactive drugs, the duration of mechanical ventilation, the days of ICU admission, the average hospitalization expenses and inhospital mortality. Results〓Compare to control group, the time of bladder pressure below 15 mmHg was decreased in the intervention group (6±0.9 d vs 9±1.8 d, P<0.05), meanwhile, the time of vasoactive drugs and ICU admission were significantly reduced, but there was not significantly difference between two groups in the duration of mechanical ventilation. There was significantly difference between two groups on the average hospitalization expenses (intervention group: 22±4.8, control group: 31±7.3, P<0.05). The inhospital mortality of intervention group was 9.5%, and 22.2% in control group. Conclusion〓Early blood purification combined with SDD can improve clinical symptoms, shorten ICU admission, and decrease mortality of SAP patients.

Key words: Critically ill patient, Blood Purition, SDD