关键词: 骨质疏松, 唑来膦酸, 骨代谢

Abstract: 【Abstract】〓Objctive〓To observe the effect of blood biochemical levels and bone turnover markers after zoledronic acid intravenous drip in the patients with postmenopausal osteoporosis. Methods〓This study were retrospectively analyzed 148 inpatient women with osteoporosis confirmed by bone mineral density examination during 2012 to 2014 in our department..The serum levels of calcium, phosphorus, creatinine, C-terminal crosslinking telopeptide of type I collagen (S-CTX), N-terminal propeptide of type I collagen (PINP) were detected and analyzed before and 24 hours after the injection of zoledronic acid were analyzed. Results〓The female patients were 65.98±9.53 years old. The concentration of serum calcium, phosphorus, creatinine, creatinine clearance, S-CTX and PINP was 2.29±0.10 mmol/L, 1.13±0.15 mmol/L, 80.84±13.7 μmol/L, 53.94±13.96 mL/min, 0.32±0.24 ng/mL,.and 44.98±27.89 ng/mL before injection and 2.13±0.14 mmol/L,.1.11±0.15 mmol/L, 85.71±12.78 μmol/L, 50.78±12.98 mL/min, 0.176±0.165 ng/mL, 45.60±26.79 ng/mL 24 hours after injection..The variation of serum calcium was decreased(P<0.05)..Fifty-five patients appeared hypocalcemia and 12 patients had a creatinine clearance lower than 35 mL/min,.but had no clinical symptoms. By contrast, the variation of serum phosphorus and creatinine was statistically significantly (P<0.05), but all the date are in normal range. The concentration of S-CTX was significantly decreased after the injection (P<0.05). The variation of PINP was not significant (P=0.65). This indicated that the injection of zoledronic acid can inhibit the activity of osteoclast immediately and has no immediate effect on the activity of osteoblast, and can cause hypocalcemia for a short time and has little influence on phosphorus metabolism and the renal function. Conclusion The injection of zoledronic acid can significantly inhibit bone resorption, and it is safe and effective.

Key words: Osteoporosis, Zoledronic acid, Bone metabolism