关键词: 强化胰岛素治疗, 重型颅脑损伤, 预后

Abstract: 【Abstract】〓Objective〓To compare the outcomes between intensive insulin therapy (IIT) and conventional insulin therapy(CIT) in patients with severe traumatic brain injury. Methods〓A retrospective study was preformed, including 116 severe traumatic brain injury patients complicated with stress hyperglycemia from our hospital during Jan 2012 to June 2014. The patients were paired and divided into two groups according to the condition, age and gender. The patients in group A were treated with IIT regimen and those in group B received CIT. The mortality, neurological function, nosocomial infection and hypoglycemia were recorded, analyzed and cpmpared between two groups. Results〓There was no statistical significance of the mortality between group A and B. Group A was associated with a lower incidence of nosocomial infection than group B. The neurological functional recovery of group A was better than that of group B. The hypoglycemia risk of group A was higher than that of group B. Conclusion Intensive insulin therapy can reduce nosocomial infection and have benefit in the neurological recover, but takes a risk of hypoglycemia.

Key words: Intensive insulin therapy, Severe traumatic brain injury, Prognosis