关键词: 胶质瘤, 手术, 放疗, 化疗, 伽玛刀

Abstract: 【Abstract】〓Objective〓To investigate the effects of postoperative concomitant therapies of high-grade glioma (gamma knife, radiotherapy, chemotherapy, synchronization chemoradiation) on delaying median relapse time and assess the clinical significance of postoperative concomitant therapy. Methods Sixty-four patients with recurring high-grade glioma patients in Deyang People's Hospital between Jan 2008 to Dec 2013 were included in the study. Of them, 28 patients were treated with only operation (A group), 36 patients treated with postoperative concomitant therapy (B group). In B group, 10 patients were treated with postoperative gamma knife(I group), 4 patients received postoperative radiotherapy (Ⅱ group), 3 patients received postoperative chemotherapy (Ⅲ group), 19 patients were treated with postoperative synchronization chemoradiation (Ⅳ group). Analyse the median relapse time among the groups. Results〓The median relapse time is 7.804 months in A group, 13.431 months in B group; 11.450 months in Ⅰ group, 8.000 months in Ⅱ group; 13.167 months in Ⅲ group, 15.659 months in Ⅳ group. It has statistical significance between A group and B group, also between A group and Ⅳ group. But it has no statistical significance among A group and other groups. Conclusion〓Synchronization chemoradiation is effective for postponing median relapse time of High-grade glioma.

Key words: Glioma, Operation, Radiotherapy, Chemotherapy, Gamma knife