关键词: 局部高渗环境, 慢性创伤性窦道, 微生物被膜

Abstract: 【Abstract】〓Objective〓To compare the effects of hypertonic saline and isotonic saline solutions on the healing of chronic traumatic wounds. Methods〓Between March 2011 and March 2014, sixty-two patients with chronic traumatic wounds were randomized to 2 groups. Thirty-one cases were treated with 28% sodium chloride medical fiber/polyester non-woven dressing (group A) and the other 31 cases, with 0.9% sodium chloride medical gauze (group B). Series of wound cultures were performed, wound conditions were assessed, and the timing of wound healing and adverse reactions were recorded. Results〓The average healing time in group A was 18.6 days. The average healing time for group B patients was 22.5 days (P<0.05). No obvious adverse effects were observed in either group. Wound cultures showed that 80% of the patients with positive pre-treatment cultures became negative after 3 days of hypertonic saline treatment whereas only 10% turned negative in group B. Conclusion〓Local hypertonic environment may significantly reduce bacteria load in chronic wounds and improve wound healing.

Key words: Local hypertonic environment, Chronic traumatic wounds, Bacterial biofilm