关键词: 动脉瘤, 蛛网膜下腔出血, CD4+CD25+调节性T细胞, 细胞因子

Abstract: 【Abstract】〓Objective〓To investigate the expression of CD4+CD25+ regulatory T cells (Treg) and its correlation with Hunt?蒺s classification for the patients with subarachnoid hemorrhage caused by intracranial aneurysm. Methods〓Fifty aneurysm patients with SAH,.50 cases with intracranial infection patients and 50 healthy people were included in this study. The peripheral blood examples were collected to detect the levels of transforming growth factors beta 1 (TGF-beta 1) and interleukin 10 (IL-10) by using flow cytometry. Levels of Tregs, TGF-beta 1 and IL-10 were compared between three groups,.and the correlation between Treg,.TGF-beta 1,.IL-10 and aneurysmal SAH Hunt classification were analyzed. Results〓The percentage composition of Treg, mean fluorescence intensity of TGF-beta 1 and IL-10 in patients with intracranial aneurysms group were significantly lower than those in healthy group,.and significantly lower than in the intracranial infection patients,.but no statistical difference was found between intracranial infection group and control group..Any of three levels of Treg,.TGF-beta 1 and IL-10 in aneurysm patients showed a negative correlation with any level of Ⅰ-Ⅴ Hunt classification(r absolute value is greater than 0.7, P<0.05),.in which the maximum correlation showed in Ⅴ level (P<0.001). Conclusion〓Treg, TGF-beta 1 and IL-10 could be protective factors of patients with intracranial aneurysm,.and lower expressions of the three factors would worsen the SAH condition.

Key words: Intracranial aneurysm, Subarachnoid hemorrhage, CD4+CD25+ regulatory T cells, Cytokines