关键词: 中性粒细胞/淋巴细胞比值, 肝细胞肝癌, 预后

Abstract: 【Abstract】〓Objective〓To investigate the postoperative neutrophil to lymphocyte ratio (NLR) change in predicting the prognosis of patients after radical resection of hepatocellular carcinoma. Methods〓Clinical data of 155 patients with hepatocellular carcinoma (HCC) who underwent radical hepatectomy in Depart ment of Hepatobiliary Surgery, the Sun Yat-sen Memorial Hospital from January 2007 to December 2009 were analyzed retrospectively. NLR changes were calculated based on the routine examination results of peripheral blood within one week before and one month after surgery. Patients were divided into the NLR decreased group and the NLR increased group according to NLR change. Kaplan-Meier method was used to analyze survival curve and Cox proportional hazard model was used to evaluate theprognostic factors of overall survival. Results〓The 5-year overall survival rates were 91.2%, 80.4%, 49.5% in NLR decreased group (108 cases) and 80.2%, 71.6%, 42.5% in NLR increased group (47 cases) (P<0.05). The median time to recurrence (TTR) was 19.9 months in NLR decreased group, and 15.2 months in NLR increased group(P<0.05). Cox multivariate analysis showed NLR change, tumor size, tumor stage were independent prognostic factors of overall survival. Conclusion〓The postoperative NLR change was an independent prognostic factor for HCC patient underwent radical hepatectomy, and patients with increased NLR indicated poor survival.

Key words: Neutrophil to lymphocyte ratio, Hepatocellular carcinoma, Prognosis