关键词: 格拉斯哥昏迷量表评分, 神经外科重症监护病房, 万古霉素耐药性肠球菌感染, 隔离

Abstract: 【Abstract】〓Objective〓To investigate the incidence and risk factors of vancomycin-resistant enterococcus(VRE)colonization in neurosurgical intensive care unit (NICU). Methods〓From September 2010 to September 2013,this retrospective study was associated with cerebrovascular disease, brain trauma, brain tumor, spinal diseases in NICU. 414 patients were enrolled in the study, demographic characteristics and risk factors were collected for statistical analysis. Results〓Among 414 patients, 52 patients were infected with VRE, 362 patients were not infected with VRE. The third generation cephalosporins was the most used antibiotics accounting for 40.4% before VRE infection. The fourth generation cephalosporins was the least used antibiotics accounting for 5.8% before the VRE infection. The univariate analysis showed that women, GCS score<8, accompanied by symptoms of diabetes, indwelling tube>4, mechanical ventilation>2 weeks, ICU time>2 weeks, nearby VRE (+) patients (P<0.05) were risk factors for VRE infection. The Logistic regression analysis showed that GCS score<8, diabetes, catheterization>2 weeks, ICU time>2 weeks, nearby VRE (+) patients were independently associated with VRE infection (P<0.05). Conclusion〓When managing the high-risk patients being prone to be infected VRE in the NICU, extreme caution should be paid upon. The most crucial interventions are careful hand washing, strict glove handling, meticulous and active screening, and complete segregation.

Key words: Glasgow coma scale score, Neurosurgical intensive care unit, Vancomycin-resistant enterococcus, Segregation