关键词: 氟比洛芬酯, 靶向镇痛, 臂丛麻醉, 止血带反应

Abstract: 【Abstract】〓Objective〓To investigate the effect on flurbiprofen targeting analgesia given by systemic vein and local vein. Methods〓Sixty patients undergoing upper extremity surgery with tourniquet were randomly and equally allocated into three groups, group A (flurbiprofen 100 mg by local vein), group B (flurbiprofen 100 mg by systemic vein) and group C (fatty emulsion). After successful brachial plexus anesthesia,the flurbiprofen was given and visual analogue scale/score (VAS) was recorded at intraoperation, postoperative 1, 4, 8, 12, 24 hour. Meanwhile, tourniquet reaction and other side-effects were observed. Results〓VAS in the each time point, tourniquet reaction and other side-effects were compared between group A and group B, which showed no significant difference. VAS in the each time point and tourniquet reaction of the group A and B were lower than that of group C (P<0.05). Conclusion〓No matter what flurbiprofen is given by systemic or local vein, it has an excellent targeting analgesic results, and it would prolong time of tourniquet reaction and reduce tourniquet reaction and other side-effect.

Key words: Flurbiprofen, Targetinganalgesia, Brachial plexusanesthesia, Tourniquet reaction