关键词: 紫杉醇, 周围神经病变, 乌司他丁

Abstract: 【Abstract】〓Objective〓To evaluate the neuroprotective effect of ulinastatin in paclitexel-induced peripheral neuropathy. Methods〓Twenty-four SD rats were randomized into 3 groups, the rats in group A were administered normal saline and those in group B were administered 25 kU/kg of ulinastatin. Rats in group C were administered 50 kU/kg of ulinastatin. Normal saline or ulinastatin were i.p. once per day for 7 consecutive days (from days 1 to 7). Paclitaxel (2 mg/kg per injection) was administered i.p. on four alternate days (Days 1, 3, 5 and 7; cumulative dose 8 mg/kg) after the injection of normal saline or ulinastatin. The paw withdraw threshold was measured using the von Frey test on day 0, 5, 8, 15, 21 and 28 d. Results〓The paw withdrawal thresholds were significantly increased in rats of group C compared to the other groups (P<0.01), and the paw withdrawal thresholds in rats of group B were higher than those in group A (P<0.05). Conclusion〓Ulinastatin can alleviate paclitexel-induced allodynia in a dose-dependent manner, and it could have a neuroprotective effect in paclitexel-induced peripheral neuropathy.

Key words: Paclitexel, Peripheral neuropathy, Ulinastatin