恶性肿瘤外周神经转移研究进展

doi:j.issn.1009-976X.2014.02.028

摘要/Abstract

摘要： 【摘要】〓外周神经浸润(PNI)与多种类型肿瘤转移、复发关系密切,是独立预后不良因素。本文从明确PNI概念开始,综述目前PNI分子和病理机制、体外内模型建立等研究进展,旨在更深入地了解PNI在肿瘤转移、复发中的作用,为进一步研究PNI机制及开发靶向PNI治疗策略奠定基础。

关键词: 外周神经浸润, 胰腺癌, 前列腺癌

Abstract: 【Abstract】〓Perineural invasion (PNI) has been reported to be closely related to the metastasis and recurrence in various cancers..For many of these malignancies,.PNI is emerging as an independent risk factor for poor prognosis. In the present study, a clear definition of PNI was laid out, and then the authors summarized current theories on the molecular mechanism and pathogenesis of PNI. In addition, current research in vitro and in vivo models for PNI were also introduced. The objectives of this review were to highlight the PNI status in predicting cancer metastasis and recurrence, as well as lead to advancements in the understanding and target therapy of this pathological entity.

Key words: Perineural invasion, Pancreatic cancer, Prostate cancer

中图分类号:

R735
R657.5

郭宇波曾林涓苏红黄开红. 恶性肿瘤外周神经转移研究进展[J]. 岭南现代临床外科, 2014, 14(02): 211-213.

Guo Yubo, Zeng Linjuan, Su Hong, Huang Kaihong. Research advances in the peripheral nerve metastasis of malignant tumors[J]. Lingnan Modern Clinics in Surgery, 2014, 14(02): 211-213.

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