关键词: 肿瘤标志物, 糖链抗原724, 癌胚抗原, 结直肠癌, 随访

Abstract: 【Abstract】〓Objective〓To detect the serum carbohydrate antigen 724 (CA724) and embryonic antigen (CEA) expression levels in colorectal cancer patients and observe the correlation between both of them. Methods〓Thirty-eight colorectal cancer patients as observer group; and 38 patients without recurrence or metastasis of cancer as control group. After taking the fasting blood, the serum levels of CA724 and CEA were detected using electrochemiluminescence method. Besides, the correlation of CA724 with CEA was tested using Pearson correlation coefficient. Results〓The serum levels of CA724 and CEA were higher in colorectal cancer patients than those in the control group. And the differences were statistically significant (P<0.01). In 76 patients, the serum levels of CA724 and CEA were significantly correlated, (correlation coefficient r=0.622, P<0.01). Conclusion〓CA724 and CEA are significantly increased in the serum of advanced colorectal cancer patients..And the serum level of CA724 is significantly correlated with the serum level of CEA in colorectal cancer patients..CA724 as an follow-up indicator of colorectal cancer after operation of is worthy of further study.

Key words: Tumor markers, Carbohydrate antigen 724, Carcinoembryonic antigen, Colorectal cancer, Follow-up