关键词: 乳腺肿瘤, 导管原位癌, 乳腺X线检查, 诊断

Abstract: 【Abstract】 Objective〓To investigate the clinical and diagnostic characteristics of mammography (MG) negative breast ductal carcinoma in situ (DCIS) with or without microinvasion. Methods〓From January 2012 to August 2013, clinicpathological data from 32 cases of MG negative DCIS or DCIS-MI were retrospectively analyzed. Results〓Of all MG negative cases, 71.9% (23/32) presented as nipple discharge, 15.6% (5/32) presented as mass, 12.5% (4/32) presented as benign look-like calcifications. High density breast, low nuclear grade, PR positive and HER2 (-) or (+) were significantly higher in MG negative cases than those in MG positive cases (P<0.05). As complementary diagnostic methods for MG negative cases,sensitivity of ultrasound and MRI were 18.7% (6/32) and 87.5% (28/32) respectively. For the cases with nipple discharge, sensitivity of fiberoptic ductoscopy was 52.2% (12/23). Conclusions〓The clinicopathological prognostic index of MG negative DCIS or DCIS-MI is relatively better. MRI and fiberoptic ductoscopy are both beneficial complementary examination for diagnosis of DCIS and DCIS-MI.

Key words: Breast neoplasm, Ductal carcinoma in situ, Mammography, Diagnosis