关键词: 乳腺肿瘤, 雌激素受体, 孕激素受体, 人表皮生长因子受体2, Ki-67

Abstract:

【Abstract】 Objective To study the clinical and pathologic characteristics of pT1a and pT1b breast carcinoma. Methods From Jan 1st, 2008 to Dec 31st, 2012, 130 patients with pT1a and pT1b breast carcinoma and 607 patients with pT1c and pT2 breast carcinoma were studied retrospectively. Clinical and pathologic factors including age,.menopausal status,.axillary lymph node metastasis, histologic grade, estrogen receptor (ER)/progesterone receptor (PR) expression, human epidermal growth factor 2 (HER-2) expression and Ki-67 index were analyzed using χ2 test. Results There was no significant difference between pT1a and pT1b breast carcinoma on all factors in this study(P>0.05). pT1a/pT1b breast carcinoma had significant lower histologic grade (G1: 59.2% vs 18.6% and 12.3%),.lower Ki-67 index.(73.8% vs 57.7% and 55.5%,those more than 14 percent) and less axillary lymph node metastasis.(86.9% vs 62.0% and 47.4%).compared with pT1c and pT2  breast carcinoma(P<0.01)..It had significant higher ER/PR expression.(76.2% vs 72.3% and 62.2%) compared with pT2 breast carcinoma (P=0.006) but not with pT1c breast carcinoma (P=0.408). HER-2 positive expression was lower but both with no significant difference (21.5% vs 22.3% and 29.7%). There was significant more patients aged younger than 35 in pT1a/pT1b breast carcinoma (21.5% vs 8.8% and 13.8%,.P<0.001 and P=0.042).while no significant difference on menopausal status. Conclusion pT1a and pT1b breast carcinoma likely have such characteristics as lower histologic grade,.lower Ki-67 index,.higher ER/PR expression and lower HER-2 positive expression compared with other larger invasive breast carcinoma..There isn?蒺t much difference between pT1a and pT1b breast carcinoma.

Key words: Progesterone receptor, Human epidermal growth factor, Ki-67, Breast neoplasms, Estrogen receptor