关键词: 胃癌;生长抑素, 炎症反应, 胃肠道功能, 胃癌根治术

Abstract:

【Abstract】Objective To investigate the effect of somatostatin on gastrointestinal function and systemic inflammatory responses in treatment of postoperative patients subjected to R2 radical gastrectomy and got R0 resection. Methods Fifty patients with R0 resection were divided into two groups(n=25, each), somatostatin group (patients received 6mg/d of somatostatin, continuous infusion for 3 days) and control group (untreated patients with somatostatin). Venous blood at first and seventh day was collected for detection of C-reactive protein,.TNF-α,IL-6,.serum albumin, prealbumin and transferrin..Also,.the gastrointestinal function restoraton was observed after administration with somatostatin. Results Serum C-reactive protein, TNF-α, IL-6, serum albumin, prealbumin and transferrin in patients of somatostatin group were increased significantly when compared with controls, but the levels in somatostatin group were lower than in control group(P<0.05). The time for restoration of gastrointestinal function in the treatment group was shortened,.showing significant differences which compared with controls.(P<0.01)..Conclusion Somatostatin can attenuate systemic inflammatory responses for patients underwent radical gastrectomy,.make a quick recovery and for the patients

Key words: Gastric cancer, Somatostatin, inflammatory response, Gastrointestinal function, Radical gastrectomy