关键词: 肝硬化, 自发性细菌性腹膜炎, 肿瘤坏死因子α, 超敏C-反应蛋白

Abstract:

【Abstract】Objective To investigate the clinical significance of TNFα and hsCRP levels in ascites for diagnosis of cirrhotic patients with spontaneous bacterial peritonitis. Methods Eighty cirrhosis patients with ascites but no clinical symptoms were selected in this study..All patients received the routine test of ascites and ascitic bacterial culture,.and they were divided into two groups, positive bacterial group and negative bacterial group(n=40, each). TNFα level in serum and ascites were measured by radio-immunity method..HsCRP was measured by ultra ion immune transmisson turbidimetry. Results The levels of TNFα and hsCRP in serum and ascites in positive ascitic fluid culture group was significantly high than those in negative ascitic fluid culture group, especially in ascites (P<0.05). There is a positive correlation between TNFα level and hs-CRP level in ascites or serum. After antibiotics treatment for one week, both levels of serum and ascites TNFα and hsCRP were significantly decreased..Conclusion Detection of TNFαand hsCRP in ascites is helpful to the early diagnosis of cirrhotic patients with spontaneous bacterial peritonitis.

Key words: Cirrhosis, Spontaneous bacterial peritonitis, TNFα, hsCRP