关键词: 青年人, 胃癌, 临床病理, 生存分析

Abstract: 【Abstract】 Objective To investigate the clinicopathological characteristics and prognosis of young patients with gastric carcinoma . Methods Retrospective analysis were conducted on 56 young patients with gastric carcinoma(age≤40 years)who were initial treated in our hospital from Jan.2005 to Dec.2010 in our hospital, and 56 cases had been chosen randomly from the old ones (age≥60 years))over the same period as the control group. Statistical analysis was performed by SPSS13.0 software package. Results In 56 gastric cancer patients of the young group ,the proportion of women was higher than men (χ2= 11.593, P = 0.001). In the young group, Gastric carcinoma more often arised in gastric antrum. The gastric cancer in the young group was mainly poor differentiated adenocarcinoma and anaplastic carcinoma; its proportion was higher than the control group (χ2=16.586, P < 0.001).The clinical stages of most young patients were Ⅲ and Ⅳ.The median survival time after resection was 39.56 months in the young group, and the total of 1，3，5-year survival rates were 80.0%, 52.0%, 24.0% respectively. In the young group the survival rate of patients who had got radical resection was higher than the patients who had undergone palliative surgery (χ2==5.836, P = 0.016).In this study , surgical methods , tumor size, pathological type, clinical stage were main factors affecting the prognosis of young patients with gastric carcinoma (P < 0.05). Conclusion Gastric cancer in the young patients is common in female. Its symptoms are always hidden and it is highly malignant, most cases are diagnosed in later period, early diagnosis and early radical resection is helpful to improve the prognosis of gastric cancer.

Key words: Young patients, Gastric cancer, Clinicpathological, Survival analysis.