关键词: 　肝再生, 肝切除术, 肝再生度, 肝再生指数

Abstract: 【Abstract】　Objective To investigate change of liver regeneration degree(LRD) and liver regeneration index(LRI) after partial hepatectomy in two different rats’liver regeneration models. Methods SD rats were randomized into 2 groups : ①liver regeneration models’group mediated by Hepatic cells proliferation (PH) ②liver regeneration models’group mediated by oval cells proliferation (2AAF/PH); LRD and LRI were calculated in the time points of 4、8、12、16、20days after liver resection. Results. PH group and 2AAF/PH group, LRD and LRI of POD(post operation day)4 increased significantly , and reached the peak on POD12 and the weight of residual liver was more than two-thirds of the total amount of regeneration. On POD20 residual liver almost reach the original liver heavy .And on POD4、8、12, LRD of PH group are higher than 2AAF/PH group ( P < 0.05). But on POD16, LRD of 2AAF/PH group are higher than PH group ( P < 0.05). On POD4、8, LRI of PH group are higher than 2AAF/PH group ( P < 0.05) and no statistical difference on POD12、16、20（P＞0.05）. Conclusions To evaluate change of liver regeneration quality, LRD and LRI are intuitive and precise index. But LRD is more accuracy than LRI in reflecting the liver regeneration regular.

Key words: Liver regeneration , Hepatectomy , LRD, LRI.