关键词: 结直肠癌, 腹腔镜手术, 羟乙基淀粉

Abstract: Objective To investigate the impacts of hydroxyethyl starch (130/ 0.4, 6%) (HS) therapy for patients after laparoscopic surgery for colorectal carcinoma. Methods Between January 2011 and July 2011, 45 patients of colorectal carcinoma after laparoscopic surgery were enrolled in this study. 23 postoperative patients in the HS group received hydroxyethyl starch (130/0.4, 6%) daily for the first three postoperative days; the other 22 postoperative patients in the albumin (ALB) group were given intravenous albumin therapy. Preoperative and postoperative heart rate, mean arterial pressure, CVP, PT, APTT, HCT, creatinine, albumin, postoperative length of stay, and postoperative anus exhaust time were compared. Results Preoperative clinical data, tumor stage, and pathological type of the two groups were comparable. There were no significant differences in heart rate, mean arterial pressure, PT, APTT, creatinine, albumin, postoperative length of stay, and postoperative anus exhaust time between the two groups (P>0.05). Compared with the ALB group and preoperation HS group, the CVP levels on the day 1, and day 3 after surgery were significantly higher in HS group (P<0.05); and the HCT levels on day 1, day 3 and day 5 after surgery were significantly lower in the HS group (P<0.05). Conclusion Hydroxyethyl starch (130/ 0.4, 6%) treatment in the early period after laparoscopic resection for colorectal carcinoma can effectively maintain hemodynamics stationary, improve colloid osmotic pressure of blood, and save the use of albumin.

Key words: Colorectal carcinoma, Laparoscopic surgery, Hydroxyethyl starch