关键词: 原发性胃腺癌, 肾小球滤过率, 临床分期, 预后

Abstract: Objective To explore the relationship between estimated glomerular filtration rate （eGFR） and clinical stage and prognosis of primary gastric adenocarcinoma （GA）. Methods A total of 102 patients with GA in Zhengzhou People's Hospital from June 2020 to June 2023 were retrospectively selected as the research objects. Clinical data such as age, gender, tumor location, maximum diameter, histological differentiation, lymph node metastasis, distant metastasis, and clinical stage were recorded. The results of related indicators of renal function within 1 week before surgery were recorded. The eGFR levels and their correlation in patients with different clinical stages were compared. Patients were divided into metastasis group and non-metastasis group according to the presence or absence of distant metastasis, and eGFR levels were compared between the two groups. The diagnostic efficacy of eGFR was analyzed by ROC curve. Kaplan-Meier method and Cox proportional hazard model were used for survival analysis to evaluate the relationship between eGFR level and prognosis. Results There were significant differences in eGFR levels between patients with different clinical stages （P<0.001）, eGFR level was negatively correlated with clinical stage （r=-0.862,P<0.001）. The level of eGFR in patients with metastasis was lower than that in patients of non-metastasis （P<0.001）. The AUC of eGFR in the diagnosis of tumor metastasis was 0.940. By eGFR stratification, the results showed that the survival time of the higher stratification group was longer than that of the lower stratification group. Cox proportional hazards regression analysis showed that eGFR level（P=0.021）, distant metastasis （P=0.038）, and degree of differentiation （P=0.009） were independent factors affecting the prognosis of GA. Conclusion The level of eGFR is closely related to the clinical stage of patients, and it is an independent factor affecting the prognosis of patientsandhas important predictive value in evaluating the metastasis and prognosis of GA.

Key words: primary gastric adenocarcinoma, estimated glomerular filtration rate, clinical staging, prognosis