乳腺腺样囊性癌两例并文献复习

doi:10.3969/j.issn.1009-976X.2023.04.010

摘要/Abstract

摘要： 目的提升对乳腺腺样囊性癌（ACCb）的认识。方法回顾性分析2018和2020年河北省人民医院收治且确诊为ACCb的2例患者的临床资料。结果 2例女性患者年龄分别为78岁和56岁,随访时间分别为12个月和39个月均无复发转移。结论 ACC为罕见的一种三阴性乳腺癌,它的影像学表现和患者的体征都不典型,容易误诊,确诊主要依赖细胞形态学和免疫组织化学,是三阴性乳腺癌中预后相对较好的类型。

关键词: 乳腺肿瘤, 三阴性乳腺癌, 腺样囊性癌, 临床病理特征, 免疫组织化学

Abstract: Objective To report two rate cases of adenoid cystic carcinoma of the breast （ACCb）. Methods Clinical data of 2 patients diagnosed with ACCb admitted to Hebei Provincial People′s Hospital in 2018 and 2020 were retrospectively analyzed. Results The ages of the two patients were 78 and 56 years old respectively, follow-ups were 39 and 12 months respectively. No recurrence and metastasis were found. Conclusion ACCb is a rare triple-negative breast cancer, its imaging and signs are untypical, and it is easy to be misdiagnosed. The diagnosis of adenoid cystic carcinoma mainly depends on cell morphology and immunohistochemistry. However, adenoid cystic carcinoma is a type of triple negative breast cancer with a relatively good prognosis.

Key words: breast tumors, triple-negative breast cancer, adenoid cystic carcinoma, clinicopathological features, immunohistochemistry

中图分类号:

R737.9

武霄勇, 闫学敏, 张佳谊, 文锦旭, 祝嘉, 王跃欣. 乳腺腺样囊性癌两例并文献复习[J]. 岭南现代临床外科, 2023, 23(04): 343-346.

WU Xiao-yong, YAN Xue-min, ZHANG Jia-yi, WEN Jin-xu, ZHU Jia, WANG Yue-xin. Adenoid cystic carcinoma of breast： two cases and review of literature[J]. Lingnan Modern Clinics In Surgery, 2023, 23(04): 343-346.

参考文献

[1] Marchiò C, Weigelt B, Reis-Filho JS.Adenoid cystic carcinomas of the breast and salivary glands (or ‘The strange case of Dr Jekyll and Mr Hyde′ of exocrine gland carcinomas)[J]. J Clin Pathol, 2010, 63(3): 220-228.
[2] Arpino G, Clark GM, Mohsin S, et al.Adenoid cystic carcinoma of the breast: molecular markers, treatment, and clinical outcome[J]. Cancer, 2002, 94(8): 2119-2127.
[3] 赵丽娜, 黄亚冰, 袁静萍. 男性乳腺腺样囊性癌一例[J].中华病理学杂志, 2021, 5(5): 535-537.
[4] Yoo SJ, Lee DS, Oh HS, et al.Male breast adenoid cystic carcinoma[J]. Case Rep Oncol, 2013, 6(3): 514-519.
[5] Romeira D, Cardoso D, Miranda H, Martins A.Adenoid cystic carcinoma: triple negative breast cancer with good prognosis[J]. BMJ Case Rep, 2016: 2016.
[6] Ghabach B, Anderson WF, Curtis RE, et al.Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study[J]. Breast Cancer Res, 2010, 12(4): R54.
[7] Tummidi S, Prasad S, Joshi D, et al.Adenoid Cystic Carcinoma Breast: a Rare Entity[J]. Indian J Surg Oncol, 2020, 11(Suppl 2): 226-231.
[8] Franceschini G, Terribile D, Scafetta I, et al. Conservative treatment of a rare case of multifocal adenoid cystic carcinoma of the breast: case report and literature review [J]. Med Sci Monit, 2010, 16(3): Cs33-39.
[9] Boujelbene N, Khabir A, Boujelbene N, et al.Clinical review-breast adenoid cystic carcinoma[J]. Breast, 2012, 21(2): 124-127.
[10] Tang W, Peng WJ, Gu YJ, et al.Imaging Manifestation of Adenoid Cystic Carcinoma of the Breast[J]. J Comput Assist Tomogr, 2015, 39(4): 523-530.
[11] Tan PH, Ellis I, Allison K, et al.The 2019 World Health Organization classification of tumours of the breast[J]. Histopathology, 2020, 77(2): 181-185.
[12] An JK, Woo JJ, Kim EK, Kwak HY.Breast adenoid cystic carcinoma arising in microglandular adenosis: A case report and review of literature[J]. World J Clin Cases, 2021, 9(25): 7579-7587.
[13] Acs G, Simpson JF, Bleiweiss IJ, et al.Microglandular adenosis with transition into adenoid cystic carcinoma of the breast[J]. Am J Surg Pathol, 2003, 27(8): 1052-1060.
[14] Ro JY, Silva EG, Gallager HS.Adenoid cystic carcinoma of the breast[J]. Hum Pathol, 1987, 18(12): 1276-1281.
[15] Vranic S, Gatalica Z, Deng H, et al.ER-α36, a novel isoform of ER-α66, is commonly over-expressed in apocrine and adenoid cystic carcinomas of the breast[J]. J Clin Pathol, 2011, 64(1): 54-57.
[16] D′Alfonso TM, Mosquera JM, MacDonald TY, et al. MYB-NFIB gene fusion in adenoid cystic carcinoma of the breast with special focus paid to the solid variant with basaloid features[J]. Hum Pathol, 2014, 45(11): 2270-2280.
[17] Martelotto LG, De Filippo MR, Ng CK, et al.Genomic landscape of adenoid cystic carcinoma of the breast[J]. J Pathol, 2015, 237(2): 179-189.
[18] Sumpio BE, Jennings TA, Merino MJ, Sullivan PD.Adenoid cystic carcinoma of the breast. Data from the Connecticut Tumor Registry and a review of the literature[J]. Ann Surg, 1987, 205(3): 295-301.
[19] Rabban JT, Swain RS, Zaloudek CJ, et al.Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers[J]. Mod Pathol, 2006, 19(10): 1351-1357.
[20] Thompson K, Grabowski J, Saltzstein SL, et al.Adenoid cystic breast carcinoma: is axillary staging necessary in all cases? Results from the California Cancer Registry[J]. Breast J, 2011, 17(5): 485-489.
[21] Cadoo KA, McArdle O, O′Shea AM, et al. Management of unusual histological types of breast cancer[J]. Oncologist, 2012, 17(9): 1135-1145.
[22] Zhang W, Fang Y, Zhang Z, Wang J.Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study[J]. Front Oncol, 2021, 11: 621012.
[23] Millar BA, Kerba M, Youngson B, et al.The potential role of breast conservation surgery and adjuvant breast radiation for adenoid cystic carcinoma of the breast[J]. Breast Cancer Res Treat, 2004, 87(3): 225-232.
[24] Youk JH, Kim MJ, Kim EK, et al.Recurrence of adenoid cystic carcinoma in the breast after lumpectomy and adjuvant therapy[J]. J Ultrasound Med, 2006, 25(7): 921-924.
[25] Khanfir K, Kallel A, Villette S, et al.Management of adenoid cystic carcinoma of the breast: a Rare Cancer Network study[J]. Int J Radiat Oncol Biol Phys, 2012, 82(5): 2118-2124.
[26] Accardo G, Capobianco AM, Torre G, et al.Adenoid cystic carcinoma of the breast and intraoperative electron radiotherapy: single case report and review of literature[J]. Future Oncol, 2022,18(7):871-881.
[27] Welsh JL, Keeney MG, Hoskin TL, et al.Is axillary surgery beneficial for patients with adenoid cystic carcinoma of the breast?[J]. J Surg Oncol, 2017, 116(6): 690-695.
[28] Zhang H, Zhang N, Moran MS, et al.Special subtypes with favorable prognosis in breast cancer: A registry-based cohort study and network meta-analysis[J]. Cancer Treat Rev, 2020, 91: 102108.