白脂素的研究进展

doi:10.3969/j.issn.1009-976X.2022.02.018

摘要/Abstract

摘要： 白脂素（Asprosin）是一种新的糖原性脂肪因子,主要在空腹时由白色脂肪组织合成并释放。Asprosin在中枢神经系统、外周组织和器官中起着复杂的作用。它与食欲、糖代谢、胰岛素抵抗（IR）、细胞凋亡等有关。最近的研究发现,Asprosin在代谢和代谢性疾病中起着重要而复杂的作用。代谢性疾病,主要包括糖尿病（DM）、非酒精性脂肪肝（NAFLD）、多囊卵巢综合征（PCOS）、心血管疾病,其主要是由于正常代谢过程的破坏。目前,这类疾病对人类健康和生命质量构成巨大威胁。本文就近年来发现的阿司匹林在代谢性疾病中的相关进展作一综述,为今后的临床诊疗提供新思路。

关键词: 白脂素, 代谢性疾病, 糖尿病, 非酒精性脂肪肝, 多囊卵巢综合征

Abstract: Asprosin is a new kind of glycogen adipokines, which is synthesized and released by white adipose tissue mainly in fasting. Asprosin plays a complex role in the central nervous system, peripheral tissues and organs. It is associated with appetite, glucose metabolism, insulin resistance （IR）, apoptosis and so on. Recent studies have found that Asprosin plays an important and complex role in metabolic and metabolic diseases. Metabolic diseases mainly include diabetes mellitus （DM）, nonalcoholic fatty liver disease （NAFLD）, polycystic ovarian syndrome （PCOS）, and cardiovascular diseases. It is mainly due to the destruction of normal metabolic processes. At present, such diseases bring a great threat to human health and the quality of life. In this paper, we reviewed the progress of asprosin in metabolic diseases in recent years, and provided new ideas for clinical diagnosis and treatment in the future.

Key words: asprosin, metabolic diseases, diabetes mellitus, nonalcoholic fatty liver disease, polycystic ovarian syndrome

中图分类号:

薛佳婧, 郭伟, 赵兵兵, 赵凌飞. 白脂素的研究进展[J]. 岭南现代临床外科, 2022, 22(02): 210-213.

XUE Jia-jing, GUO Wei, ZHAO Bing-bing, ZHAO Ling-fei. New progress in the study of Asprosin[J]. Lingnan Modern Clinics In Surgery, 2022, 22(02): 210-213.

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