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岭南现代临床外科 ›› 2022, Vol. 22 ›› Issue (02): 115-119.DOI: 10.3969/j.issn.1009-976X.2022.02.001

• 专家笔谈 •    下一篇

中晚期肝癌转化治疗中的几个焦点问题

龙吟, 宋兴东, 张磊*   

  1. 中山大学孙逸仙纪念医院肝胆外科,广州 510120
  • 通讯作者: *张磊,zhangl9@mail.sysu.edu.cn
  • 作者简介:张磊 医学博士,主任医师,博士生导师 中山大学孙逸仙纪念医院肝胆外科副主任;中国医师协会快速康复外科委员会委员;中国医师协会肝癌专业委员会委员;中国医师协会胆道外科委员会委员;国际肝胆胰协会中国分会快速康复委员会委员兼秘书;广东医学会外科分会常务委员;广东医学会微创学会常务委员;广东医学会肝胆胰分会胰腺学组副组长;《岭南现代临床外科》副主编,编辑部主任
  • 基金资助:
    广东省自然科学基金(2017A030313871)

Several focus issues of conversion therapies for intermediate-advanced hepatocellular carcinoma

LONG Yin, SONG Xing-dong, ZHANG Lei   

  1. Department of Hepatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
  • Online:2022-04-20 Published:2022-05-25
  • Contact: ZHANG Lei, zhangl9@mail.sysu.edu.cn

摘要: 我国大部分肝癌患者初诊时已处于中晚期,失去了通过手术切除获得长期生存的机会。当前系统治疗的发展、局部治疗技术的进步有望让更多中晚期不可切除肝癌患者从转化治疗中获益。经过初步探索,局部联合系统治疗的多模式、高强度的转化治疗方案展现了可喜的转化成功率。然而,关于如何选择转化治疗目标人群及转化方案、何时序贯手术切除在内的一系列问题尚存在争议。笔者回顾国内外相关研究进展,围绕转化治疗中的几个焦点问题进行探讨。

关键词: 肝细胞癌, 转化治疗, 降期治疗, 手术切除

Abstract: Most patients with hepatocellular carcinoma are diagnosed at intermediate-advanced stage in China, losing the chance of long-term survival through surgical resection. In recent years, locoregional therapy and systemic therapies of hepatocellular carcinoma have achieved great progress and more patients with intermediate-advanced unresectable hepatocellular carcinoma are expected to benefit from conversion therapies. After preliminary exploration, the multi-mode and high-intensity conversion therapies through combining locoregional therapy and system therapy has shown a gratifying success rate. However, there is still no consensus on the target population, regimen options and operation opportunity of conversion therapies. The paper reviews the domestic and foreign research progress and discusses several focus issues of conversion therapies for intermediate-advanced hepatocellular carcinoma.

Key words: hepatocellular carcinoma, conversion therapies, downstaging therapies, surgical resection

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