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岭南现代临床外科 ›› 2021, Vol. 21 ›› Issue (06): 658-662.DOI: 10.3969/j.issn.1009-976X.2021.06.014

• 论著与临床研究 • 上一篇    下一篇

术前单次小剂量甲强龙对经皮肾镜碎石取石术后全身炎症反应综合征影响的回顾性研究

赵朋朋, 黄剑华, 徐战平*   

  1. 佛山市中医院泌尿外科,广东佛山 528000
  • 通讯作者: * 徐战平,Email:xuzhanping2004@163.com
  • 基金资助:
    佛山市卫生和计生局医学科研课题(20190092)

Retrospective analysis for the effect of a single low dose of methylprednisolone on systemic inflammatory response syndrome after percutaneous nephrolithotomy

ZHAO Peng-peng1, HUANG Jian-hua, XU Zhan-ping   

  1. Department of Urology, Foshan Hospital of Traditional Chinese Medicine, Guangdong 528000,China
  • Received:2021-07-28 Online:2021-12-20 Published:2022-01-19
  • Contact: XU Zhan-ping, xuzhanping2004@163.com

摘要: 目的 探讨术前单次小剂量甲强龙对经皮肾镜碎石取石术(PCNL)术后全身炎症反应综合征(SIRS)的影响。方法 回顾性收集2019年1月至2021年5月期间在我院泌尿外科接受PCNL的患者资料315例,经排除最终纳入237例。根据术前是否使用甲强龙分为两组,对比两组术后SIRS的发生率及其他预后指标。结果 甲强龙组患者120例,对照组117例,两组患者术前基线临床资料无统计学差异(P>0.05)。甲强龙组术后2小时降钙素原(PCT)及超敏C反应蛋白(HSCRP)、术后1天PCT及HSCRP低于对照组(P<0.05);甲强龙组术后当天发热率、术后住院时间低于对照组(P<0.05);两组术后SIRS发生率、术后血培养阳性率、脓毒血症发生率、重症监护病房(ICU)住院率均无统计学差异。结论 术前单次小剂量甲强龙可降低PCNL患者术后PCT及HSCRP水平、手术当天发热率、术后住院时间,但对术后SIRS的发生无预防作用。

关键词: 甲强龙, 经皮肾镜碎石取石术, 全身炎症反应综合征, 糖皮质激素

Abstract: Objective To explore the effect of a single low dose of methylprednisolone on systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCNL). Methods There were 315 patients diagnosed with renal calculi and received PCNL in the urology Department of our hospital from January 2019 to May 2021. After exclusion, 237 cases were included in the statistical analysis. And the patients were divided into two groups according to whether methylprednisolone was used before the operation. The incidence of SIRS and the data of other prognostic indicators were recorded. Results There were 120 patients in the methylprednone group and 117 patients in the control group. There was no significant different between the two groups about preoperative baseline indicators(P<0.05). Indicators: Compared with the control group, the PCT and HSCRP of the methylprednone group were lower at postoperative hour two and atpostoperative day one(P<0.05). Clinical outcomes showed incidence of fever on the day of surgery and postoperative hospital stay in the methylprednone group were lower than that in the control group(P<0.05). There was no significant difference between the two groups in the incidence of SIRS, positive blood culture, sepsis, ICU stay(P>0.05). Conclusion A single low dose of methylprednone before PCNL was beneficial for decreasing levels of PCT and HSCRP, caused a shorter postoperative hospital stay. It has no preventive effect on the occurrence of postoperative SIRS.

Key words: methylprednisolone, percutaneous nephrolithotripy, systemic inflammatory response synodrome, glucocorticoid

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