关键词: 甲强龙, 经皮肾镜碎石取石术, 全身炎症反应综合征, 糖皮质激素

Abstract: Objective To explore the effect of a single low dose of methylprednisolone on systemic inflammatory response syndrome （SIRS） after percutaneous nephrolithotomy （PCNL）. Methods There were 315 patients diagnosed with renal calculi and received PCNL in the urology Department of our hospital from January 2019 to May 2021. After exclusion, 237 cases were included in the statistical analysis. And the patients were divided into two groups according to whether methylprednisolone was used before the operation. The incidence of SIRS and the data of other prognostic indicators were recorded. Results There were 120 patients in the methylprednone group and 117 patients in the control group. There was no significant different between the two groups about preoperative baseline indicators（P<0.05）. Indicators： Compared with the control group, the PCT and HSCRP of the methylprednone group were lower at postoperative hour two and atpostoperative day one（P<0.05）. Clinical outcomes showed incidence of fever on the day of surgery and postoperative hospital stay in the methylprednone group were lower than that in the control group（P<0.05）. There was no significant difference between the two groups in the incidence of SIRS, positive blood culture, sepsis, ICU stay（P>0.05）. Conclusion A single low dose of methylprednone before PCNL was beneficial for decreasing levels of PCT and HSCRP, caused a shorter postoperative hospital stay. It has no preventive effect on the occurrence of postoperative SIRS.

Key words: methylprednisolone, percutaneous nephrolithotripy, systemic inflammatory response synodrome, glucocorticoid