关键词: 脾, 转移性肿瘤, 病理诊断

Abstract: Objective To investigate the clinicopathological features of splenic metastatic tumor in order to improve the understanding of the disease. Methods The clinical data and pathological features of 56 patients with splenic metastatic tumor in Sun Yat-sen Memorial Hospital of Sun Yat-sen University from January 2012 to December 2020 were analyzed retrospectively, and the related literatures were reviewed. The tumor of lymphatic hematopoietic system involving spleen was excluded. Results There were 139 cases of splenic tumors, accounting for 11.82% of the cases of splenic surgery in our hospital in the same period. There were 44 cases of splenic lymphohematopoietic system-related tumors and 95 cases of non-lymphohematopoietic tumors, including 56 cases of metastatic tumors. Metastatic tumors accounted for 4.76% of the cases of splenic surgery in our hospital in the same period, and 40.29% of splenic neoplastic lesions in our hospital in the same period. Among the 56 patients with splenic metastatic tumors, there were 26 males and 30 females. The age of onset was ranged from 30 to 76 years old, and the average age was 53 years old. Fifty-six cases of splenic metastatic tumors included pancreatic tumor （19 cases）, ovarian cancer （13 cases）, gastric tumor （9 cases）, liver cancer （6 cases）, intestinal adenocarcinoma （4 cases）, appendiceal mucinous adenocarcinoma （2 cases）, uterine choriocarcinoma （1 case）, breast invasive ductal carcinoma （1 case） and lung cancer （1 case）. The pathological morphology of metastatic tumor was similar to that of primary tumor, and immunohistochemical staining further confirmed the diagnosis. Conclusion The primary tumors of splenic metastases come from a wide range of sources, and the most common primary tumors are high-grade serous adenocarcinoma of the ovary and ductal adenocarcinoma of the pancreas. The combination of clinical, imaging and pathology is helpful to the correct diagnosis.

Key words: spleen, metastatic tumor, pathological diagnosis.