关键词: 妊娠, 哺乳, 骨质疏松, 骨折

Abstract: Objective Pregnancy and lactation-associated osteoporosis （PLO） is a rare form of osteoporosis causing significant disability. This case could help increase awareness of the disease and accumulate the experience in diagnosis and treat. Methods The Clinical characteristics were analyzed retrospectively in a patient with PLO regard to the elaborate diagnosis and treatment. Results The PLO patient was young women, with regular menstruation, back pain and limited mobility in the early lactation. Biochemical examination was basically normal, and imaging examination showed multiple vertebral compression fractures, bone mineral density examination indicates osteoporosis. Lactation was terminated after exclusion of other osteoporosis causes and received treatment of calcium, vitamin D, calcitonin, and biphosphonates. The back pain disappeared obviously. The findings are discussed in view of the current literature. Conclusions PLO must be kept in mind in the differential diagnosis in patients presenting with low back pain during or after pregnancy. Most PLO patients have a good prognosis by stopping breastfeeding, giving calcium, vitamin D, bisphosphonates and other drugs, but they should be followed up for a long time.

Key words: pregnancy, lactation, osteoporosis, fracture