关键词: 自身免疫性胰腺炎, 治疗, 体会

Abstract: Objective To explore the regularity of autoimmune pancreatitis （AIP） and provide the reference for the clinical practice. Methods From July 2013 to May 2017, we analyzed the result of treated autoimmune pancreatitis in 13 cases in Baiyin First People′s Hospital of Gansu Province. The clinical manifestation, symptom, imaging, laboratory examination, therapeutic effect, and prognosis were summarized. Results Of 13 patients, clinical presentation included cutaneous or sclera icterus in 8 cases （61%）, abdominal pain in 7 cases （54%）, abdominal distention in cases （38%）, anorexia in cases （38%）, and weight loss in 4 cases （31%）. The CT showed that localized enlargement of the pancreas in 7 cases （54%） and diffuse enlargement of the pancreas in 6 cases （46%）. MRCP showed that stenosis of the lower part of the common bile duct and the bile duct dilatation in narrow distal segment in 8 cases, a typical “mouse-tail sign” in 2 cases, primary sclerosing cholangitis in 5 cases, a generalized lymphadenopathy in 4 cases, rheumatoid arthritis in 3 cases, and type 2 diabetes in 4 cases of, 3 cases of whom had a family history of type 2 diabetes. Among 12 patients treated with hormone therapy plus ursodeoxycholic acid, 3 patients obviously improved and healed after retrograde cholangiopancreatography treatment due to severe jaundice. A patient was misdiagnosed as cholangiocarcinoma and made in surgical treatment. The follow-up period was 1-3 years, after discharge. The mean follow-up period was 1.5 years. 2 patients with poor dependency relapse after the onset of medicine for 5 days, 10 days in March and May he onset of medicine for 5 days, 10 days. after a follow-up reexamination, treatment. All 12 cases were healed and 2 patients recurred after treatment for 8 months and 17 months, respectively. One case died after treatment 19 months. The cause of death was pancreatic cancer. In order to achieve better curative effect. Conclusion AIP patients should treate with hormone, ursodeoxycholic acid, and ERCP, combined with comprehensive treatment after discharge from the hospital.

Key words: autoimmune pancreatitis, treatment, clinical experience