关键词: 乳腺纤维囊性病, 乳管灌洗, 三苯氧胺, 非甾体抗炎药外用

Abstract: Objective To compare short-term effects on fibroadenosis by three different methods. Methods The data of outpatients diagnosed with fibroadenosis from January 2018 to June 2020 were analyzed. A total of 85 patients with breast pain that affect daily life （60 patients with symptoms of cyclic mastalgia and 48 with noncyclic mastalgia） were assigned to three groups, galactophore lavage group （lavage group, n=25）, toral tamoxifen group （tamoxifen group, n=30） and topical NSAIDs group （topical NSAIDs group, n=30）, and treatment for 3 months. Visual analogue scale （VSA） was used to score pain, and color Doppler ultrasound was used to evaluate the changes in breast fibrocystic lesions after treatment. Results One month after treatment, mastalgia in patients of the three groups was relieved in varying degrees, and the lavage group and the tamoxifen group were significantly better than those before treatment and the topical NSAIDs group. VAS scores In the three groups decreased significantly at 1 month, 2 months, 3 months, 4 months and 6 months after treatment, but there was no significant change at 3 months, 4 months and 6 months. After 6 months of follow-up, color Doppler ultrasound showed that the lesions in lavage group shrank, especially the cysts shrank significantly, and most of the cysts became clear. In tamoxifen group, 13 cases of lesions shrank, including 11 cases of cysts shrank, 10 cases of cysts became clear. In NSAIDs group, 4 cases shrank, 3 cases increased, 6 cases of cysts became clear. There was no change in BIRADS grade among the three groups. Conclusion Breast lavage, drug and topical NSAIDs can significantly improve mastalgia in patients with fibroadenosis, but not effectively alleviate the lesions and pathological changes.

Key words: fibroadenosis, breast lavage, tamoxifen, topical NSAIDs