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岭南现代临床外科 ›› 2021, Vol. 21 ›› Issue (01): 11-16.DOI: 10.3969/j.issn.1009-976X.2021.01.003

• 专家笔谈 • 上一篇    下一篇

结直肠癌肝转移预后评分系统的现状及临床应用

张果, 张瑞, 陈进宏*   

  1. 复旦大学附属华山医院普外科,上海200040
  • 通讯作者: *陈进宏,Email: jinhongch@hotmail.com
  • 作者简介:陈进宏,复旦大学附属华山医院外科,教授、主任医师、博士生导师
    临床工作主要从事原发性肝癌和结直肠癌肝转移等肝胆外科疾病的诊治,擅长腹腔镜手术。研究工作主要包括肝胆疾病的基础及临床。负责国家重大科技专项肝癌项目1项(1539.50万元),国家自然科学基金3项,市科委和复旦大学课题各1项。
    目前担任世界腹腔镜肝脏学会创始会员;上海市医学会肝脏外科学组副组长;中华医学会外科学分会青委会委员;中华医学会外科学分会脾与门脉高压学组委员;中国医师协会结直肠癌肝转移专委会副秘书长;中国医师协会外科医师分会机器人委员会青委会委员;中国医药教育协会肝胆胰专业委员会委员;中国研究型医院学会分子诊断医学专业委员会委员;国家自然科学基金评审专家;中华医学科技奖评审专家等。
    获“上海市杰出青年医学人才”,“复旦大学明日之星”等荣誉称号。
  • 基金资助:
    十三五重大科技专项(2017ZX10203207); 国家自然科学基金(82070655)

Current status and clinical application of the prognostic scoring system for colorectal liver metastasis

ZHANG Guo, ZHANG Rui, CHEN Jin-hong   

  1. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Online:2021-02-20 Published:2021-04-08

摘要: 结直肠癌是中国第二常见的恶性肿瘤,其中约50%的患者最终会发生肝转移。有效的全身治疗和积极包括手术在内的局部治疗,是提升结直肠癌肝转移患者疗效的关键。肝切除术后复发是导致结直肠癌肝转移患者死亡的主要原因,不同复发风险的患者治疗选择也有所不同,因此建立有效的结直肠癌肝转移预后评分系统,以指导其个体化治疗至关重要。临床危险评分(CRS)是目前结直肠癌肝转移患者应用最广泛的预后评分系统。其他预后评分系统还包括肿瘤负荷评分(TBS)、GAME评分、CERR评分等。预后评分系统的不断完善可以更好地帮助临床医生预测结直肠癌肝转移病人预后,对高危患者采取更积极的干预手段,合理有效地延长患者生命。

关键词: 结直肠癌, 结直肠癌肝转移, 预后评分系统, 临床危险评分

Abstract: Colorectal cancer is the second most common malignant tumor in China, and about 50% of patients will have liver metastases. Effective systemic treatment and active local treatment including surgery are the key to improving the efficacy of patients with colorectal liver metastasis. Recurrence after hepatectomy is the main cause of death in patients with colorectal liver metastasis. The treatment options for patients with different recurrence risks are also different. Therefore, it is very important to establish an effective prognostic scoring system for colorectal liver metastasis to guide its individualized treatment. Clinical Risk Score (CRS) is currently the most widely used prognostic scoring system for patients with colorectal liver metastasis. Other prognostic scoring systems include Tumor Burden Score (TBS), Genetic And Morphological Evaluation (GAME) score, and Comprehensive Evaluation of Relapse Risk (CERR) score. The continuous improvement of the prognosis scoring system can better help clinicians predict the prognosis of patients with colorectal liver metastasis, and adopt more active intervention methods for high-risk patients to reasonably and effectively prolong the lives of patients.

Key words: colorectal cancer, Colorectal Liver Metastasis, prognosis scoring system, clinical risk score

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