关键词: 亚急性期, 溶栓治疗, 下肢深静脉血栓形成, 介入治疗

Abstract: Objective To investigate clinical outcome of thrombolytic therapy for subacute deep venous thrombosis （sDVT） and to summarize our single-center experience. Methods During the period from 2014 to 2019, those patients who were diagnosed with sDVT and accepted thrombolytic therapy were included, and their clinical and follow-up data were retrospectively collected and analyzed. Results A total of 23 patients were involved, including 11 males and 12 females. The average age was 35.2±11.7 years old. Of these, thrombolytic therapy was performed in 8 patients via dorsalis pedis vein, and in 7 patients via popliteal vein. Femoral artery access was established in 1 patient, while femoral vein access in another patient. The remaining 6 patients experienced thrombolytic therapy via femoral vein in combination with popliteal vein. Assistant strategies included ballon dilation, stent implantation or thrombectomy were performed in 6 patients. During the period of thrombolytic therapy, 1 patient experienced gastrointestinal bleeding and recovered after conservative treatment. After thrombolytic therapy, angiography or ultrasound revealed that complete and partial thrombus dissolution was achieved in 6 and 8 patients, while no thrombus dissolution was found in 9 patients. Complete or partial thrombus dissolution was confirmed in all 6 patients accepted assistant strategies. The thigh and calf circumference were decreased by 2.8（2.4）cm （P=0.003） and 3.8（2.9） cm （P=0.001） after therapy, respectively. Conclusion Thrombolytic therapy is safe and effective for patients with sDVT. The access used for therapy should be established flexibly according to lesion range and thrombolytic effect. Assistant strategies, including balloon, stent and thrombectomy, can improve the effectiveness of thrombolytic therapy.

Key words: deep venous thrombosis, subacute stage, interventional strategies, thrombolytic therapy