关键词: 恶性胶质瘤, 作用机制, 研究进展, 抗血管治疗药物

Abstract: Malignant glioma is the most common and invasive primary brain tumor in adults， and its significant neurological and incurable properties bring great pain and serious medical burden to patients and their families. The median survival of patients is less than 15 months due to the current standard treatment regimen that is difficult to achieve. Angiogenesis is a hallmark of malignant glioma and has become an important new therapeutic target. This article reviews the mechanism of anti-angiopathy and the clinical application of anti-angiogenic drugs in the treatment of malignant glioma， and briefly discusses the research progress of anti-angiogenic drugs for malignant glioma.

Key words: mechanism, malignant glioma, anti-angiogenic therapeutic drugs, research progress