关键词: 凝血, 血流动力学, 全麻术, 超前镇痛, 丙帕他莫

Abstract: ［Abstract］ Objective To investigate the effect of propranolol on analgesia and hemodynamics and postoperative adverse reactions in general cannula and extubation. Methods A total of 80 patients undergoing general anesthesia for tracheal intubation in our hospital aged 30-65 years with a body weight of 48-75 kg were enrolled in this study. ASA was classified as grade Ⅰ and grade Ⅱ. Randomly divided into： saline control group （control group） and propatinam group （experimental group）. The two groups were given intravenous drip of saline 100 mL or propatinol 2 g/100 mL 15 minutes before anesthesia respectively. Before tracheal intubation （T1）， 5 min after intubation （T2）， 5 min before extubation （T3）， immediately after extubation （T4）， extubation MAP （mean arterial pressure）， heart rate （HR） and central venous pressure （CVP） at 5 min （T5） were measured and analyzed by using CA-7000 automatic coagulation analyzer and ancillary reagents The two groups of patients were respectively treated with propantamil， platelet aggregation rate， prothrombin time （PT）， thrombin time （APTT）， partial prothrombin time （APTT） Fibrinogen concentration （FIB）. In addition， RS restlessness score， Ramsay sedation score and VAS score were used to assess perioperative and postoperative agitation， sedation and pain. Results There was no significant difference in HR， MAP and CVP between T1 and T3 in both groups （P>0.05）. Compared with T3 at T2， T4 and T5， MAP and HR in both groups increased， However， MAP and HR at each time point in the experimental group were significantly lower than those in the control group （P<0.05）. In addition， CVP in both groups only increased significantly in T4； PT， TT， APTT and FIB at each time point in both groups were not significantly different between groups and between groups. In addition， the RS and Ramsay scores of the test group after extubation were significantly lower than those of the control group， and the VAS scores at 1 h and 6 h were also lower than those of the control group. Conclusion The prophylaxis of propranolol in patients with general anesthesia can maintain the hemodynamics of intubation and extubation in patients with general anesthesia， which can reduce and reduce postoperative pain and do not affect patients Perioperative coagulation function， can be safely used for general anesthesia of the analgesic.

Key words: Propacetamol, Advanced analgesia, Hemodynamics, Blood clotting, General anesthesia