关键词: 头颈部鳞癌, 未分化癌, 动态对比增强磁共振成像

Abstract: ［Abstract］ Objective To evaluate the feasibility of quantitative DCE-MRI parameters in the differential diagnosis of head and neck squamous cell carcinoma and undifferentiated carcinoma. Methods Forty-two patients with head and neck squamous cell carcinoma （HNSCC） and 53 patients with undifferentiated carcinoma （UC） were enrolled. The mean age was 63±17 years， 45±23 years， and a total of 95 patients were examined with MRI before treatment， and QDCE-MRI quantitative parameters were evaluated to analyze pathological types and MRI parameters （including volume transport constant （Ktrans）， reverse reflux rate constant （Kep）， extravascular extracellular space （Ve）， plasma The relationship between volume fraction （Vp）， peak time （TTP）， maximum concentration （MAXCon）， area under the curve （AUC）， and maximum slope （MAXSlope）. Results The values of Ktrans， Kep， TTP， MAXSlope of HNSCC were 0.09620±0.3894 min-1， 0.6527±0.2608 min-1， 2.9640±0.8409 min，1.8499±0.7698， The value of Ktrans， Kep， TTP， MAXSlope of HNSCC is 0.1432±0.0527 min-1， 0.8520±0.2166 min-1， 2.1055±0.9605 min， 2.1543±0.8767（mean±SD）. The differences of Ktrans， Kep， TTP and MAXSlope between HNSCC group and UC group were statistically significant （P<0.05）. Conclusion DCE-MRI quantitative parameters including Ktrans， Kep， TTP， MAXSlope can be used to identify head and neck squamous cell carcinoma and undifferentiated cancer.

Key words: undifferentiated carcinoma, DCE-MRI, Squamous cell carcinoma of the head and neck