关键词: 纳米碳, 甲状腺乳头状癌, 甲状腺球蛋白, 中央区淋巴结

Abstract: ［Abstract］ Objective To explore the application of carbon nanoparticle （CNP） during total thyroidectomy for papillary carcinoma， especially for central neck dissection and postoperative serum thyroglobulin （Tg）. Methods 112 patients were recruited retrospectively among those who performed total thyroidectomy and central neck dissection from November 2017 to September 2018. 57 of them receiving injection of CNP intraoperatively were defined as CNP group while others were control group. Number of lymph nodes （LNs） resected， rate of metastasis and postoperative Tg were compared between two groups. Results Amount of central LNs detected from CNP group and control group were 568 and 504 respectively. No significance could be discovered between them （P=0.508）. Neither did significance between LNs involved of two groups， which was 240 and 222 respectively （P=0.965）. However， metastatic rate of black?dyed LNs was significantly lower than that of undyed （21.2% vs 59.1%， P=0.000）. In terms of postoperative Tg level， there was no significance between two groups （0.43 ng/mL vs 0.19 ng/mL， P=0.401）. Conclusion The present study did not show that the use of carbon nanoparticles significantly increased the number of lymph nodes resection in the central region. The metastatic rate of black?dyed LNs is lower than that of undyed. CNP would not be benefit for improvement of postoperative short?term oncologic outcomes among patients with papillary thyroid carcinoma.

Key words: carbon nanoparticle, central lymph node, thyroglobulin, papillary thyroid carcinoma