关键词: 人类表皮生长因子受体2, 穿刺活检, 雌激素受体、孕激素受体, 乳腺癌

Abstract: ［Abstract］ Objective To investigate the effect of the consistency between preoperative needle biopsy and classification surgical specimens on the treatment of early breast cancer. Methods Forty?eight patients with breast tumors treated with surgical operation in our hospital were selected as the research subjects. Puncture biopsy and surgical resection biopsy were carried out on all the patients above. The immunohistochemical results of ER， PR， HER2 and Ki?67 in puncture tissues were analyzed according to the standard of surgical resection biopsy. Results Forty?two cases were positive and 6 cases were negative by surgical resection. The positive predictive values of ER， PR， HER2 and Ki?67 in puncture tissues were 97.44%， 93.75%， 89.65% and 92.59%， the negative predictive values were 55.56%， 25%， 15.79% and 19.05%， the sensitivity was 92.86%， 71.43%， 61.91% and 47.62% and the specificity was 75%， 33.33%， 27.27% and 21.43%. Conclusion The combined detection of ER， PR， HER2 and Ki?67 by immunohistochemistry in puncture biopsy can accurately reflect the histopathology of breast cancer and provide a reference for the treatment of breast cancer.

Key words: estrogen receptor, breast cancer, puncture biopsy, progesterone receptor, human epidermal growth factor receptor 2